eISSN: 1509-572x
ISSN: 1641-4640
Folia Neuropathologica
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3/2018
vol. 56
 
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abstract:
Case report

A rare case of intracranial malignant triton tumor arising in the middle cranial fossa: a case report and review of the literature

Eros Bruzzone, Ilaria Melloni, Salvina Barra, Giulio Fraternali Orcioni, Leonardo Cocito

Folia Neuropathol 2018; 56 (3): 229-234
Online publish date: 2018/09/28
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We describe a rare case of intracranial malignant triton tumor (MTT) arising in the middle cranial fossa in a 74-year-old female patient who had previously been exposed to radiation in the Chernobyl disaster. The patient underwent a surgical subtotal removal of the mass and radiation therapy, but the progression-free survival was only 2.5 months and death occurred four months after the onset of symptoms. MTTs are rare aggressive tumors arising from the nerve sheath showing rhabdomyosarcomatous differentiation and associated with a poor prognosis. The intracranial location is very rare, and only 10 cases, including the present report, have been described so far. Among intracranial MTTs, the cerebellopontine angle is the most common location. Neurofibromatosis type 1 (NF-1) and radiation exposure are risk factors as for MTTs located in other sites. The gold standard therapy is surgical excision followed by radiation therapy, but the prognosis is usually very poor.
keywords:

malignant triton tumor (MTT), rare intracranial tumors, nerve sheath tumors

references:
Best PV. Malignant triton tumour in the cerebellopontine angle. Report of a case. Acta Neuropathol 1987; 74: 92-96.
Beuvon F, Criscuolo JL, Salmon RJ, Laurent M. Neurosarcome radio-induit. Aspects clinique, histologique et immunohistochimique. Bull Cancer 1991; 78: 619-626.
Bornstein-Quevedo L, Peralta-Olvera F, Marhx-Bracho A, Rodríguez-Jurado R, De Leon-Bojorge B. Cerebral malignant nerve sheath tumor, triton tumor variant: case report. Pediatr Dev Pathol 2003; 6: 168-172.
Cavanagh JB. Effects of x-irradiation on the proliferation of cells in peripheral nerve during Wallerian degeneration in the rat. Br J Radiol 1968; 41: 275-281.
Coffin CM, Dehner LP. Peripheral neurogenic tumors of the soft tissues in children and adolescents: a clinicopathologic study of 139 cases. Pediatr Pathol 1989; 9: 387-407.
Comey CH, McLaughlin MR, Jho HD, Martinez AJ, Lunsford LD. Death from a malignant cerebellopontine angle triton tumor despite stereotactic radiosurgery. Case report. J Neurosurg 1998; 89: 653-658.
De Cauwer H, Bogers JP, Duwel V, den Hauwe V, Croese P, Van Marck E An intracerebral intraparenchymatous triton tumor in a man with neurofibromatosis J Neurol 2007; 254: 1009-1011.
Drozdovitch V, Bouville A, Chobanova N, Filistovic V, Ilus T, Kovacic M, Malátová I, Moser M, Nedveckaite T, Völkle H, Cardis E. Radiation exposure to the population of Europe following the Chernobyl accident. Radiat Prot Dosimetry 2007; 123: 515-528.
Engel EE, Brassesco MS, Valera ET, Nogueira-Barbosa MH, Yamashita ME, Scrideli CA, Tone LG. Clinico-genetic aspects of a pediatric non-neurofibromatosis type 1 malignant triton tumor with loss of chromosome X. Pediatr Blood Cancer 2012; 59: 1320-1323.
Ghosh A, Sastri SB, Srinivas D, Mahadevan A, Anandappa CB, Shankar SK. Malignant triton tumor of cervical spine with hemorrhage. J Clin Neurosci 2011; 18: 721-723.
Gong L, Liu XY, Zhang WD, Han XJ, Yao L, Zhu SJ, Lan M, Li YH, Zhang W. A rare case of malignant triton tumor in the cerebellopontine angle. Diagn Pathol 2012; 7: 43.
Han DH, Kim DG, Chi JG, Park SH, Jung HW, Kim YG. Malignant triton tumor of the acoustic nerve. Case report. J Neurosurg 1992; 76: 874-877.
Jaing TH, Chuang CC, Jung SM, Wu CT, Tseng CK, Chen CS. Malignant triton tumor of the cervical spine: report of one case and review of the literature. Pediatr Neonatol 2015; 56: 58-61.
Kamperis E, Barbetakis N, Asteriou C, Kleontas A, Christoforidou V. Malignant triton tumor of the chest wall invading the lung. A case report and literature review. Hippokratia 2013; 17: 277-280.
Kamran SC, Howard SA, Shinagare AB, Krajewski KM, Jagannathan JP, Hornick JL, Ramaiya NH. Malignant peripheral nerve sheath tumors: prognostic impact of rhabdomyoblastic differentiation (malignant triton tumors), neurofibromatosis 1 status and location. Eur J Surg Oncol 2013; 39: 46-52.
Köstler WJ, Amann G, Grunt TW, Singer CF, Schneider SM, Brodowicz T, Tomek S, Zielinski CC. Recurrent malignant Triton tumour: first report on a long time survivor. Oncol Rep 2003; 10: 533-535.
Koutsimpelas D, Brieger J, Heinrich U, Torzewski M, Sommer C, Mann WJ. Cytogenetic analysis of a malignant triton tumour by comparative genomic hybridization (CGH) and review of the literature. Eur Arch Otorhinolaryngol 2011; 268: 1391-1396.
Koutsopoulos AV, Mantadakis E, Katzilakis N, Lagoudaki ED, de Bree E, Stiakaki E, Kalmanti M. Long-term survival of a patient with a neurofibromatosis type 1 associated retroperitoneal malignant triton tumor after multi-modality treatment. Clin Neuropathol 2011; 30: 333-335.
Lau OD, Nabili V, Lai C, Kirsch CF, Tantiwongkosi B, Abemayor E. Pathology quiz case 1. Diagnosis: Sinonasal malignant Triton tumor (MTT) with intracranial extension. Arch Otolaryngol Head Neck Surg 2010; 136: 929, 931.
Li Z, Xiang J, Yan S, Gao F, Zheng S. Malignant triton tumor of the retroperitoneum: a case report and review of the literature. World J Surg Oncol 2012; 10: 96.
Locatelli P. Formation de membres surnuméraires. C R Assoc Anat 20e Reunion, Turin 1925; 279-282.
Mae K, Kato Y, Usui K, Abe N, Tsuboi R. A case of malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation: malignant triton tumor. Case Rep Dermatol 2013; 5: 373-378.
Masson P. Recklinghausen’s neurofibromatosis, sensory neuromas and motor neuromas. In: Emanuel Libman Anniversary. Vol. 2. International Press, New York 1932; 793-802.
McConnell YJ, Giacomantonio CA. Malignant triton tumors – complete surgical resection and adjuvant radiotherapy associated with improved survival. Surg Oncol 2012; 106: 51-56.
Mijović Z, Mihailović D, Zivković N, Kostov M, Zivković S, Stojanović N. A rare case of retroperitoneal malignant Triton tumor invading renal vein and small intestine. Vojnosanit Pregl 2013; 70: 322-325.
Nirhale DS, Parasnis A, Bora C, Gupta R, Aulakh P. Retroperitoneal peripheral nerve sheath tumour of triton type – a case report. Indian J Surg 2013; 75 (Suppl 1): 12-14.
Nitsche M, Reible M, Pflüger KH, Bergmann M, Hermann RM. Malignant triton tumor of the sciatic nerve as a secondary malignancy after extended field radiotherapy and chemotherapy of Hodgkin’s disease. Case Rep Oncol 2014; 7: 239-245.
Nuclear Energy Agency. Chernobyl: Assessment of Radiological and Health Impacts. 2002 Update of Chernobyl: Ten Years On. Chapter IV: Doses Estimates. NEA-OECD, Paris 2002; 61-75.
Ozer E, Erkilic S, Bayazit YA, Mumbuc S, Aydin A, Kanlikama M. Malignant triton tumor of the supraclavicular region arising after radiotherapy. Auris Nasus Larynx 2002; 29: 405-407.
Parham DM. Pathologic classification of rhabdomyosarcomas and correlations with molecular studies. Mod Pathol 2001; 14: 506-514.
Prieto R, Pascual JM, García-Cabezas MA, López-Barea F, Bar­rios L, González-Llanos F. Low-grade malignant triton tumor in the lumbar spine: a rare variant of malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation. Neuropathology 2012; 32: 180-189.
Ren W, Xu X, Yan J, Qian X, Liu B. Malignant triton tumor of the anterior mediastinum: a case report. Oncol Lett 2014; 7: 807-810.
Shetty PK, Baliga SV, Balaiah K. Malignant triton tumor: a rare case. Indian J Surg 2013; 75 (Suppl 1): 362-365.
Smith RE, Kebriaei MA, Gard AP, McComb RD, Bridge JA, Lennarson PJ. Intracranial malignant triton tumor in a patient with neurofibromatosis type 1: case report and review of the literature. Brain Tumor Pathol 2014; 31: 149-154.
Takahashi Y, Sugita Y, Abe T, Yuge T, Tokutomi T, Shigemori M. Intraventricular malignant triton tumour. Acta Neurochir (Wien) 2000; 142: 473-476.
Tanimura A, Nagayama K, Nishimura T. Malignant schwannoma associated with embryonal rhabdomyoblastic foci in a single tumor. Acta Pathol Jpn 1984; 34: 133-138.
Terzic A, Bode B, Gratz KW, Stoeckli SJ. Prognostic factors for the malignant triton tumor of the head and neck. Head Neck 2009; 31: 679-688.
Thoennissen NH, Schliemann C, Brunnberg U, Schmidt E, Staebler A, Stegger L, Bremer C, Schleicher C, Mesters RM, MüllerTidow C, Berdel WE. Chemotherapy in metastatic malignant triton tumor: report on two cases. Oncol Rep 2007; 18: 763-767.
Woodruff JM, Chernik NL, Smith MC, Millett WB, Foote FW. Peripheral nerve tumors with rhabdomyosarcomatous differentiation (malignant “Triton” tumors). Cancer 1973; 32: 426-439.
Woodruff JM, Kourea HP, Louis DN, Scheithauer BW. Malignant peripheral nerve sheath tumor (MPNST). In: Kleihues P, Cavenee WK (eds.). Pathology and Genetics of Tumours of the Nervous System. IARC Press, Lyon 2000; 172-174.
Woodruff JM, Perino G. Non-germ-cell or teratomatous malignant tumors showing additional rhabdomyoblastic differentiation, with emphasis on the malignant triton tumor. Semin Diagn Pathol 1994; 11: 69-81.
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