Alzheimer’s disease-related a-synuclein gene expression in CA3 subfield of hippocampus in post-ischemic brain during 2-year survival

Ryszard Pluta; Anna Bogucka-Kocka; Jacek Bogucki; Janusz Kocki; Stanisław Czuczwar

doi:10.5114/fn.2025.152012

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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2/2025
vol. 63

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abstract:

Original paper

Alzheimer’s disease-related a-synuclein gene expression in CA3 subfield of hippocampus in post-ischemic brain during 2-year survival

Ryszard Pluta

¹

,

Anna Bogucka-Kocka

²

,

Jacek Bogucki

³

,

Janusz Kocki

⁴

,

Stanisław J. Czuczwar

¹

Department of Pathophysiology, Medical University of Lublin, Poland
Chair and Department of Biology and Genetics, Medical University of Lublin, Poland
Faculty of Medicine, John Paul II Catholic University of Lublin, Poland
Department of Clinical Genetics, Medical University of Lublin, Poland

Folia Neuropathol 2025; 63 (2): 120-126

DOI: https://doi.org/10.5114/fn.2025.152012

Online publish date: 2025/07/04

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In this study, we investigated whether changes in the expression of the a-synuclein gene occur and participate in post-ischemic brain neurodegeneration of Alzheimer’s disease phenotype. The current study assessed the expression of the a-synuclein gene by RT-PCR after 10-minute brain ischemia in rats in CA3 area with survival at 2, 7, and 30 days and 6, 12, 18, and 24 months. Reduced gene expression was observed at 2 days, 6, and 24 months after ischemia. In the remaining observation periods, i.e., 7 and 30 days and 12 and 18 months, its expression was significantly above control values. In post-ischemic brain, where survival times ranged from 2 days to 2 years, we noted biphasic changes in overexpression of the a-synuclein gene in the CA3 area of the hippocampus. The presented data correlate very well with previous studies, which found an increase in protein levels in the brain and strong immunostaining for a-synuclein after ischemia. Finally, the results clearly indicate that changes in the expression of the a-synuclein gene play an important role in acute and secondary brain injury and the development of brain neurodegeneration after ischemia of Alzheimer’s disease phenotype. Overall, studies show that a-synuclein is an attractive target for the development of new therapies to minimize ischemic brain damage and neurological dysfunction.

keywords:

Alzheimer’s disease-related a-synuclein gene expression in CA3 subfield of hippocampus in post-ischemic brain during 2-year survival

Ryszard Pluta 1 , Anna Bogucka-Kocka 2 , Jacek Bogucki 3 , Janusz Kocki 4 , Stanisław J. Czuczwar 1

brain ischemia, a-synuclein, CA3 area, hippocampus, neurodegeneration, Alzheimer’s disease, gene

Ryszard Pluta

¹

,

Anna Bogucka-Kocka

²

,

Jacek Bogucki

³

,

Janusz Kocki

⁴

,

Stanisław J. Czuczwar

¹