eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
Current issue Archive Manuscripts accepted About the journal Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank
2/2022
vol. 47
 
Share:
Share:
more
 
 
abstract:
Case report

Autoimmune sclerosing cholangitis might be triggered by SARS-CoV-2 infection in a child – a case report

Katarzyna Zdanowicz
1
,
Anna Bobrus-Chociej
1
,
Anna Kopiczko
1
,
Mirosława Uścinowicz
1
,
Monika Tomczuk-Ostapczuk
1
,
Jacek Janica
1
,
Joanna Maria Łotowska
1
,
Irena Białokoz-Kalinowska
2
,
Dariusz Marek Lebensztejn
1

1.
Medical University of Bialystok, Bialystok, Poland
2.
Lomza State University of Applied Sciences, Lomza, Poland
Cent Eur J Immunol 2022; 47 (2): 183-187
Online publish date: 2022/05/30
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
The spectrum of liver involvement during coronavirus disease 2019 (COVID-19) is broad and mainly includes elevated liver enzymes and cholestasis. Severe acute respiratory syndrome corona- virus-2 (SARS-CoV-2) infection most often leads to a transient moderate increase in liver enzymes that is not accompanied by disturbances in the synthetic function of the liver. However, there is increasing evidence that SARS-CoV-2 infection is associated with the development of autoimmune disorders. The pathogenesis of autoimmune hepatobiliary diseases is not fully understood, taking into account genetic and environmental factors such as viral infections. We present a pediatric case of autoimmune sclerosing cholangitis (ASC), which was diagnosed 2 months after SARS-CoV-2 infection. To the best of our knowledge, ASC potentially triggered by COVID-19 has not been reported in pediatric patients. Further studies are needed to describe the clinical impact of the development of autoimmune liver diseases potentially associated with SARS-CoV-2 infection in pediatric patients. Our observations indicate that children with liver injury potentially caused by COVID-19 require long-term monitoring of liver function parameters.
keywords:

children, COVID-19, autoimmune hepatitis/primary sclerosing cholangitis overlap syndrome

Quick links
© 2022 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.