eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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4/2017
vol. 42
 
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abstract:
Review paper

Butyrophilins: an important new element of resistance

Magdalena Malinowska
,
Beata Tokarz-Deptuła
,
Wiesław Deptuła

(Centr Eur J Immunol 2017; 42 (4): 399-403)
DOI: https://doi.org/10.5114/ceji.2017.72806
Online publish date: 2017/12/30
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Butyrophilins belonging to the immunoglobulin superfamily are new immune system regulators because they are present on lymphocytes, dendritic cells, monocytes, macrophages, neutrophils and eosinophils, and they exert a stimulatory and (or) inhibitory effect on them. The role of butyrophilins is associated and results from their similarity to the regulatory B7 protein family involved in the modulation of immune phenomena. Butyrophilins are glycoproteins built of two extracellular immunoglobulin domains, stabilized with disulfide bonds: constant IgC, and variable IgV and a transmembrane region. Most of these proteins contain a conserved domain encoded by a single exon – B30.2, also referred to as PRYSPRY. In humans, the family of butyrophilins includes 7 butyrophilin proteins, 5 butyrophilin-like proteins and the SKINT-like factor. Butyrophilins have been also demonstrated to play a role in various infections, e.g. tuberculosis or diseases that include sarcoidosis, systemic lupus erythematosus, rheumatoid arthritis, genetic metabolic diseases, ulcerative colitis, cancer and kidney disease.
keywords:

butyrophilins, butyrophilin-like protein, immune system

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