eISSN: 1509-572x
ISSN: 1641-4640
Folia Neuropathologica
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vol. 60
Review paper

Cerebral ischemia reperfusion injury: from public health perspectives to mechanisms

Gulnara Kapanova
1, 2
Gulnara Tashenova
3, 4
Aida Akhenbekova
Adem Tokpınar
Seher Yılmaz

  1. Al-Farabi Kazakh National University, Almaty 050040, Kazakhstan
  2. Scientific Center of Anti-Infectious Drugs, Almaty 050040, Kazakhstan
  3. Asfendiyarov Kazakh National Medical University, Almaty 050040, Kazakhstan
  4. JCS “Scientific Center of Pediatrics and Children Surgery”, Kazakhstan
  5. Department of Anatomy, Faculty of Medicine, Yozgat Bozok University, Yozgat, Turkey
Folia Neuropathol 2022; 60 (4): 384-389
Online publish date: 2022/11/19
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Cerebral ischemia/reperfusion injury has emerged as an intricate mechanism. However, identification of wide-ranging mechanisms which mechanistically regulate reperfusion injuries have significantly improved our understanding. Recent advancements in our knowledge about the molecular consequences of ischemia and reperfusion might be advantageous in the development of innovative therapeutic strategies for the treatment of patients with ischemia and reperfusionassociated organ dysfunction and tissue inflammation. Some of the extensively studied mechanisms of reperfusion injury consist of oxidative stress, mitochondrial mechanisms, infiltration of leukocytes, activation/aggregation of the platelets, complement activation, and disruption of the blood-brain-barrier (BBB), which eventually results in the brain oedema or haemorrhagic transformations. In this review, we have attempted to provide a review of the protein networks involved in the regulation of cerebral ischemia reperfusion injury and how different natural products have shown potential in the amelioration of reperfusion induced injuries.

mTOR, PI3K/AKT, cerebral ischemia, stroke

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