eISSN: 2720-5371
ISSN: 1230-2813
Advances in Psychiatry and Neurology/Postępy Psychiatrii i Neurologii
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vol. 33
Case report

Coexistence of multiple sclerosis and systemic lupus erythematosus – a case report

Maciej Dubaj
Aleksandra Dembowska
Karol Bigosiński
Ewa Belniak
Konrad Rejdak

  1. Student Scientific Society, Chair and Department of Neurology, Medical University of Lublin, Poland
  2. Chair and Department of Neurology, Medical University of Lublin, Poland
Adv Psychiatry Neurol 2024; 33 (1): 39–42
Online publish date: 2024/01/17
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Multiple sclerosis (MS) and systemic lupus erythematosus (SLE) are two autoimmune diseases that are relatively common, especially in women. However, it is extremely rare for them to coexist in a single patient (only 18 cases have been recorded worldwide). Both affect the nervous system and may manifest in identical ways. This creates significant difficulties, both in terms of dia­gnosis and choice of appropriate therapy.

Case description:
A 54-year-old female patient with quadriparesis, superficial sensory disturbance and gait and balance disorders was diagnosed with primary progressive MS according to McDonald’s criteria. The magnetic resonance images were typical for MS. Pre­viously, in 2013, she was diagnosed with SLE, treated successfully, and is currently in remission. After excluding neuropsychiatric lupus, ocrelizumab treatment was administered, with good clinical results.

Adequate differentiation (magnetic resonance imaging, analysis of cerebrospinal fluid, clinical observation) as to whether the patient’s symptoms are related to MS or to SLE nervous system involvement is the basis for proper diagnosis and treatment.


systemic lupus erythematosus, differential diagnosis, multiple sclerosis, coexistent disease

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