eISSN: 2081-2841
ISSN: 1689-832X
Journal of Contemporary Brachytherapy
Current Issue Archive Supplements Articles in Press Journal Information Aims and Scope Editorial Office Editorial Board Register as Author Register as Reviewer Instructions for Authors Abstracting and indexing Subscription Advertising Information Links
SCImago Journal & Country Rank

Interview with Professor Janusz Skowronek
ABS 2015
1/2018
vol. 10
 
Share:
Share:
more
 
 
abstract:
Original paper

Dosimetric analysis of the effects of the bladder volume on organs at risk (OAR) in high-dose-rate intracavitary brachytherapy in carcinoma cervix – an institutional study

Ashutosh Das Sharma, Jyoti Poddar, U Suryanarayan K, Sonal Patel Shah, Ankita Parikh, Vimesh Mehta, Tarun Kumar

J Contemp Brachytherapy 2018; 10, 1: 26–31
Online publish date: 2018/02/28
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Purpose
The purpose of this study was to establish a dosimetric correlation between the bladder volume and its effects on the dose received by the organs at risk (OARs) (urinary bladder, rectum, and sigmoid) during computed tomography (CT)-guided high-dose-rate (HDR) brachytherapy in carcinoma cervix, and to determine an optimum bladder volume to limit the dose to OARs.

Material and methods
Seventy-five intracavitary applications in patients of carcinoma cervix (stage IIB, IIIA, IIIB, IVA) treated with external beam radiotherapy with concurrent chemotherapy followed by CT-based HDR intracavitary brachytherapy (tandem and ovoid type) at our institute between July 2014 to January 2016 were studied. The bladder volume at the time of imaging was noted and was correlated with the radiation dose received by bladder, rectum, and sigmoid colon.

Results
Dose volume histogram (DVH) parameters of the bladder increases by elevating the volume of the bladder. Rectum dose does not follow a continuous increasing trend. It increases up to a bladder volume of 110 cc and then starts decreasing. The highest rectal dose observed was in the bladder volume, range 70-110 cc. The minimum doses were recorded when the bladder volume was > 170 cc. Sigmoid colon DVH parameters follow a similar trend as that of the rectum.

Conclusions
A relationship exists between the volume of the OARs and the dose received by them. A bladder volume of about 70 cm3 or less proved better for achieving the prescribed dose limits of bladder, rectum, and sigmoid. The correlations between the bladder volume and the doses received by the OARs were not significant.

keywords:

image-guided brachytherapy, bladder volume, dosimetry, cervical carcinoma

references:
Siavashpour Z, Aghamiri MR, Jaberi R et al. Optimum organ volume ranges for organs at risk dose in cervical cancer intracavitary brachytherapy. J Contemp Brachytherapy 2016; 8: 135-142.
Gellrich J, Hackenberg OW, Oehlschlager S et al. Manifestation, latency and management of late urological complications after curative radiotherapy for cervical carcinoma. Onkologie 2003; 26: 334-340.
Fellner C, Potter R, Knocke TH et al. Comparison of radiography and computed tomography-based treatment planning in cervix cancer in brachytherapy with specific attention to some quality assurance aspects. Radiother Oncol 2001; 58: 53-62.
Haie-Meder C, Pötter R, Van Limbergen E et al. Recommendations from Gynaecological (GYN) GECESTRO Working Group (I): concepts and terms in 3D image-based 3D treatment planning in cervix cancer brachytherapy with emphasis on MRI assessment of GTV and CTV. Radiother Oncol 2005; 74: 235-245.
Pötter R, Haie-Meder C, Van Limbergen E. Recommendations from gynaecological (GYN) GEC ESTRO working group (II): concepts and terms in 3D image-based treatment planning in cervix cancer brachytherapy-3D image-based anatomy, radiation physics, radiobiology. Radiother Oncol 2006; 78: 67-77.
Patra NB, Manir KS, Basu S. Effect of bladder distension on dosimetry of organs at risk in computer tomography-based planning of high dose rate intracavitary brachytherapy for cervical cancer. J Contemp Brachytherapy 2013; 5: 3-9.
Sun LM, Huang HY, Huang EY. A prospective study to assess the bladder distension effects on dosimetry in intracavitary brachytherapy of cervical cancer via computer tomography assisted techniques. Radiother Oncol 2005; 77: 77-82.
Adli M, Garipagaoglu M, Kocak Z. Effect of bladder distension on bladder base dose in gynaecological intracavitary high dose rate brachytherapy. Br J Radiol 2009; 82: 243-248.
ICRU Report 89, Prescribing, Recording, and Reporting Brachytherapy for Cancer of the Cervix. www.icru.org
Cengiz M, Gurdalli S, Selek U. Effect of bladder distension on dose distribution of intracavitary brachytherapy for cervical cancer. Three-dimensional computed tomography plan evaluation. Int J Radiat Oncol Biol Phys 2008; 70: 464-468.
Yashamita H, Nakagawa K, Okuma K. Correlation between bladder volume and irradiated dose of small bowel in CT-based planning of Intracavitary Brachytherapy for Cervical Cancer. Jpn J Clin Oncol 2012; 42: 302-308.
Han K, Milosevic M, Fyles A et al. Trends in the utilization of brachytherapy in cervical cancer in the United States. Int J Radiat Oncol Biol Phys 2013; 87: 111-119.
Stewart AJ, Cormack RA, Lee H et al. Prospective clinical trial of bladder filling and three-dimensional dosimetry in high-dose-rate vaginal cuff brachytherapy. Int J Radiat Oncol Biol Phys 2008; 72: 843-848.
Kirisits C. The EQD2 concept for practical reporting for cervix brachytherapy. http://www.aoic.net/elekta/elk1402archive/D201Kirisits.pdf
Orton CG, Wolf-Rosenblum S. Dose dependence of complication rates in cervix cancer radiotherapy. Int J Radiat Oncol Biol Phys 1986; 12: 37-44.
Stryker JA, Bartholomew M, Velkley DE. Bladder and rectal complications following radiotherapy for cervix cancer. Gynaecol Oncol 1988; 29: 1-11.
Kim RY, Shen S, Lin HY. Effects of bladder distension on organs at risk in 3D image-based planning of intracavitary brachytherapy for cervical cancer. Int J Radiat Oncol Biol Phys 2010; 76: 485-488.
Harmon G, Chinsky B, Surucu M et al. Bladder distension improves the dosimetry of organs at risk during intracavitary cervical high-dose-rate brachytherapy. Brachytherapy 2016; 15: 30-34.
 
Quick links
© 2018 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe