Two types of hypersensitivity reaction including anaphylaxis and symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) after aminopenicillin administration in the same patient

Lesia Rozłucka; Radosław Gawlik; Joanna Glück

doi:10.5114/pja.2023.132963

eISSN: 2391-6052
ISSN: 2353-3854

Alergologia Polska - Polish Journal of Allergology

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Opis przypadku

Dwa typy reakcji nadwrażliwości: anafilaksja oraz symetryczna, wyprzeniowa i zgięciowa osutka wywołana lekiem (SDRIFE), które wystąpiły u pacjenta po zażyciu aminopenicyliny

Lesia Rozłucka

¹

,

Radosław Gawlik

¹

,

Joanna Glück

¹

Department of Internal Medicine, Allergology and Clinical Immunology, Medical University of Silesia, Katowice, Poland

Alergologia Polska – Polish Journal of Allergology 2023; 10, 4: 315–318

DOI: https://doi.org/10.5114/pja.2023.132963

Data publikacji online: 2023/12/15

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AMA

Rozłucka L, Gawlik R, Glück J. Two types of hypersensitivity reaction including anaphylaxis and symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) after aminopenicillin administration in the same patient. Alergologia Polska - Polish Journal of Allergology. 2023;10(4):315-318. doi:10.5114/pja.2023.132963.

APA

Rozłucka, L., Gawlik, R.,  & Glück, J. (2023). Two types of hypersensitivity reaction including anaphylaxis and symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) after aminopenicillin administration in the same patient. Alergologia Polska - Polish Journal of Allergology, 10(4), 315-318. https://doi.org/10.5114/pja.2023.132963

Chicago

Rozłucka, Lesia, Radosław Gawlik,  and Joanna Glück. 2023. "Two types of hypersensitivity reaction including anaphylaxis and symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) after aminopenicillin administration in the same patient". Alergologia Polska - Polish Journal of Allergology 10 (4): 315-318. doi:10.5114/pja.2023.132963.

Harvard

Rozłucka, L., Gawlik, R.,  and Glück, J. (2023). Two types of hypersensitivity reaction including anaphylaxis and symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) after aminopenicillin administration in the same patient. Alergologia Polska - Polish Journal of Allergology, 10(4), pp.315-318. https://doi.org/10.5114/pja.2023.132963

MLA

Rozłucka, Lesia et al. "Two types of hypersensitivity reaction including anaphylaxis and symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) after aminopenicillin administration in the same patient." Alergologia Polska - Polish Journal of Allergology, vol. 10, no. 4, 2023, pp. 315-318. doi:10.5114/pja.2023.132963.

Vancouver

Rozłucka L, Gawlik R, Glück J. Two types of hypersensitivity reaction including anaphylaxis and symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) after aminopenicillin administration in the same patient. Alergologia Polska - Polish Journal of Allergology. 2023;10(4):315-318. doi:10.5114/pja.2023.132963.

Metryki PlumX:

We present a rare case of a patient who experienced both immediate and delayed types of drug hypersensitivity reaction (DHR) to aminopenicillin with good tolerance of another β-lactam. A 56-year-old female patient reported allergic reactions to several antibiotics. After the co-administration of nonsteroidal anti-inflammatory drugs (NSAIDs) and amoxicillin/clavulanic acid the patient presented with anaphylactic shock. At the same time, the patient reported good amoxicillin tolerance. During hospitalization, DHR to NSAIDs was excluded by oral provocation. Due to the unclear history of β-lactam allergy, after negative skin test results, an oral provocation test with amoxicillin was performed. Four hours after the administration of the last dose, the patient developed symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) with temperature increase to 38.5°C. Laboratory tests showed increased inflammatory parameters. After treatment with dexamethasone, paracetamol and bilastine, a gradual regression of skin rash and normalization of inflammatory parameters were observed. Further work-up confirmed good tolerance of cefuroxime axetil.

Dwa typy reakcji nadwrażliwości: anafilaksja oraz symetryczna, wyprzeniowa i zgięciowa osutka wywołana lekiem (SDRIFE), które wystąpiły u pacjenta po zażyciu aminopenicyliny

Lesia Rozłucka 1 , Radosław Gawlik 1 , Joanna Glück 1

Lesia Rozłucka

¹

,

Radosław Gawlik

¹

,

Joanna Glück

¹