eISSN: 1897-4317
ISSN: 1895-5770
Gastroenterology Review/Przegląd Gastroenterologiczny
Current issue Archive Manuscripts accepted About the journal Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank
3/2020
vol. 15
 
Share:
Share:
more
 
 
abstract:
Original paper

Efficacy and safety of laparoscopic hepatectomy for hepatocellular carcinoma comorbid with cirrhosis

Yoshihiro Inoue
1
,
Keisuke Yokohama
2
,
Hideko Ohama
2
,
Yusuke Tsuchimoto
2
,
Tetsuji Terazawa
2
,
Akira Asai
2
,
Shinya Fukunishi
2
,
Junji Okuda
1
,
Kazuhide Higuchi
2
,
Kazuhisa Uchiyama
1

1.
Department of General and Gastroenterological Surgery, Osaka Medical College Hospital, Osaka, Japan
2.
Second Department of Internal Medicine, Osaka Medical College Hospital, Osaka, Japan
Gastroenterology Rev 2020; 15 (3): 225–233
Online publish date: 2020/09/19
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Introduction
Laparoscopic hepatectomy (LH) is very difficult to perform in patients with cirrhosis because of the haemor- rhagic and fibrotic nature of the liver, although there are various advantages to laparoscopic surgery.

Aim
To investigate the surgical outcomes, and efficacy and safety of LH versus open hepatectomy (OH) for hepatocellular carcinoma (HCC) resection.

Material and methods
A total of 112 patients with cirrhosis, who underwent hepatectomy, were analysed retrospectively. We investigated the safety and efficacy of LH for HCC with cirrhosis. Student’s t and χ2 tests, Mann-Whitney’s U test, Wilcoxon’s signed-rank test, and Fisher’s exact test were used in the statistical analysis.

Results
Seventy-one patients underwent LH, and 41 underwent OH. The conversion rate from LH to OH was 12.7%. After propensity score matching, the estimated blood loss was significantly lower in the LH group than in the OH group (25 vs. 310 ml; p < 0.001), and there was a significant difference between the groups in the operative time (p = 0.091). The LH group had complication rates of 3.6% and 0% for refractory ascites and pleural effusion, respectively, while those were 17.9% and 10.7%, respectively, in the OH group (p = 0.019 and p = 0.005, respectively). The LH group had no mortality, whereas the OH group had a mortality rate of 10.7% (p = 0.038). The postoperative length of stay was significantly longer in the LH group than in the OH group (9 days vs. 14 days) (p = 0.002).

Conclusions
LH can be performed safely for HCC with cirrhosis. More favourable results are achieved with LH than with OH in terms of surgical outcomes.

keywords:

liver cirrhosis, laparoscopic hepatectomy, hepatocellular carcinoma

Quick links
© 2021 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe