eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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vol. 48
Clinical immunology

Efficacy evaluation of direct antiviral drugs against hepatitis B virus in improving the degree of liver fibrosis

Liang Miao
1, 2
Lihua Cao
Guiqiang Wang

Peking University First Hospital, China
The Third Hospital of Qinhuangdao, China
Cent Eur J Immunol 2023; 48 (2): 126-134
Online publish date: 2023/06/01
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The aim of the study was to find an ideal index reflecting inflammation and fibrosis for patients after antiviral treatment, and compare it with imaging examination (liver stiffness measurement – LSM) and traditional liver fibrosis models (APRI and FIB-4).

Material and methods:
A total of 77 chronic hepatitis B (CHB) patients who achieved a sustained virological response (SVR) after entecavir (ETV) treatment were included, and the changes of various clinical indicators before and after treatment were compared.

After 78 weeks of ETV treatment, WBC and PLT of 77 patients were significantly increased, while ALT, AST and total bilirubin were significantly decreased (p < 0.05). There was no significant difference in serum creatinine (Cr) or blood urea nitrogen (BUN) compared to the values before treatment (p > 0.05). The three non-invasive liver fibrosis indexes, namely, LSM, APRI and FIB-4, were significantly decreased in 77 patients compared to the values before treatment (p < 0.001).

Acoustic radiation force impulse (ARFI), fibrosis-4 (FIB-4), aspartate aminotransferase-to-platelet ratio index (APRI) have a high consistency with the grading of liver fibrosis, and can be used to evaluate the severity of liver fibrosis. Among them, ARFI has good diagnostic value for the classification of different degrees of liver fibrosis and the best diagnostic accuracy.


direct antiviral drugs, hepatitis B, entecavir, liver fibrosis, liver stiffness, noninvasive

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