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Folia Neuropathologica
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4/2019
vol. 57
 
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abstract:
Original paper

Epigallocatechin gallate enhances the motor neuron survival and functional recovery after brachial plexus root avulsion by regulating FIG4

Yinjuan Tang
1
,
Jianjun Wang
2
,
Shengjie Wan
2
,
Lanbing Luo
2
,
Yuxia Qiu
2
,
Shiyin Jiang
2
,
Guihua Yue
2
,
Yumei Tang
2
,
Weijun Tang
3

1.
Department of Basic Medical Sciences, Xiangnan University, Chenzhou, Hunan Province, China
2.
Department of Clinical Medicine, Xiangnan University, Chenzhou, Hunan Province, China
3.
Department of Pharmacy, Xiangnan University, Chenzhou, Hunan Province, China
Folia Neuropathol 2019; 57 (4): 340-347
DOI: https://doi.org/10.5114/fn.2019.90819
Online publish date: 2019/12/19
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The survival of motor neurons (MNs) is the key to recovery of the motor function after brachial plexus root avulsion (BPRA). (-)-epigallocatechin-3-gallate (EGCG) exerts neuroprotective roles in neurons under different pathological conditions. However, the role of EGCG in regulating motor neurons under BPRA remains to be unclear. In the present study, we investigated the functional role of EGCG both in vitro and in vivo. In an in vitro study, we observed that EGCG obviously increased the cell survival rate of MNs and FIG4 protein levels compared with the vehicle control, with a peak level observed at 50 µM; EGCG can also upregulate FIG4 to reduce the cell death of MNs and increase the neurite outgrowth under oxidative stress; moreover, EGCG can upregulate FIG4 to promote the functional recovery and the survival of MNs in the ventral horn in mice after BPRA. These combined results may lay the foundation for EGCG to be a novel strategy for the treatment of BPRA.
keywords:

motor neurons, brachial plexus root avulsion, (-)-epigallocatechin-3-gallate (EGCG), neurodegenerative diseases, FIG4
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