Fatty liver disease

Iwona Mikołajczyk; Mariusz Rosołowski; Aleksy Łukaszyk

eISSN: 1897-4317
ISSN: 1895-5770

Gastroenterology Review/Przegląd Gastroenterologiczny

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6/2008
vol. 3

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abstract:

Fatty liver disease

Iwona Mikołajczyk

,

Mariusz Rosołowski

,

Aleksy Łukaszyk

Przegląd Gastroenterologiczny 2008; 3 (6): 276–282

Online publish date: 2009/01/16

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Some individuals develop fatty liver disease. It is now well established that hepatic steatosis is frequently associated with obesity, insulin resistance and type 2 diabetes mellitus, or with excessive alcohol intake. Although clearly different in their metabolic origins, it is recognised that nonalcoholic and alcoholic fatty liver disease share several features and, most importantly, that accumulation of fat in the liver is not
a benign condition. Excess fat increases the vulnerability of hepatocytes to potential harmful effects of metabolic stress imposed by cytokines, viral infections and oxidative agents. As a consequence, hepatic steatosis is a factor predisposing to development of fibrosis and cirrhosis. This article reviews pathophysiology, diagnostic and therapeutic methods according to the currently recommended standards.

keywords:

Fatty liver disease

Iwona Mikołajczyk , Mariusz Rosołowski , Aleksy Łukaszyk

fatty liver, nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, alcohol-induced liver disease, oxidative stress, metabolic syndrome

Iwona Mikołajczyk

,

Mariusz Rosołowski

,

Aleksy Łukaszyk