Combined lipid disorders, including increased plasma triglycerides levels, low HDL-C, and small, dense LDL particles, comprise atherogenic dyslipidaemia. Observational and clinical studies have shown that these lipid abnormalities are strongly associated with increased risk of macro- and microvascular events even in patients with LDL-C level at goal after statin therapy. Combination pharmacotherapy may significantly improve lipid profile and have a significant impact on cardiovascular risk reduction, which is reflected in the non-HDL cholesterol concentration, the secondary target of treatment in the latest guidelines.