eISSN: 2081-2841
ISSN: 1689-832X
Journal of Contemporary Brachytherapy
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1/2019
vol. 11
 
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abstract:
Original paper

Five-year outcome of ultrasound-guided interstitial permanent 125I seeds implantation for local head and neck recurrent tumors: a single center retrospective study

Ping Jiang, Junjie Wang, Weiqiang Ran, Yuliang Jiang, Suqing Tian, Haitao Sun

J Contemp Brachytherapy 2019; 11, 1: 28–34
Online publish date: 2019/02/28
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Purpose
The aim of this study was to evaluate the efficacy and safety of interstitial permanent low-dose-rate ultrasound-guided 125I seeds implantation of local head and neck recurrent tumors.

Material and methods
Sixty-four consecutive patients, with 81 lesions in total, underwent permanent implantation of 125I seeds under ultrasound guidance. Post-operative dosimetry was performed for all patients. Follow-up period ranged 103.5 months (median, 14 months).

Results
Among the 81 lesions, the totally response rate was 80.2%, and 22 (27%) and 43 (53%) lesions showed complete and partial remission. The 1-, 3-, and 5-year tumor control rates were 75.2%, 73.0%, and 69.1%, respectively. The results for cervical lymph node recurrence were better than those for recurrence or residual disease of primary head and neck neoplasms, with 5-year local control rates of 72.7% and 39.9%, respectively. D90 was an independent prognostic factor of the tumor control, and lesion recurrence location and time to tumor progression were prognostic factors of survival. As of the date of follow-up, 22 of 64 patients were still alive. The 1-, 3-, and 5-year overall survival rates were 57.4%, 31%, and 26.6%, respectively, with a median survival of 20 months. Grade 4 skin ulceration was seen in two patients; grade 1 or 2 skin reactions were seen in 11 patients (17%) who had received external beam radiotherapy before. Other severe complications were absent.

Conclusions
Interstitial permanent implantation of 125I seeds under ultrasound guidance is feasible, efficacious, and safe for refractory head and neck metastasis or recurrence.

keywords:

head and neck cancer, recurrence, cervical lymph node metastasis, ultrasound-guided, brachytherapy

references:
Ferlay J, Shin HR, Bray F et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010; 127: 2893-2917.
Srivastava P, Kingsley PA, Srivastava H et al. Persistent post-radiotherapy pain and locoregional recurrence in head and neck cancer-is there a hidden link? Korean J Pain 2015; 28: 116-121.
Knappe M, Louw M, Gregor RT. Ultrasonography-guided fine-needle aspiration for the assessment of cervical metastases. Arch Otolaryngol Head Neck Surg 2000; 126: 1091-1096.
Zhu L, Jiang Y, Wang J et al. An investigation of 125I seed permanent implantation for recurrent carcinoma in the head and neck after surgery and external beam radiotherapy. World J Surg Oncol 2013; 11: 60.
Baatenburg DJR, Rongen RJ, Lameris JS et al. Metastatic neck disease. Palpation vs ultrasound examination. Arch Otolaryngol Head Neck Surg 1989; 115: 689-690.
Blanco RG, Califano J, Messing B et al. Transcervical ultrasonography is feasible to visualize and evaluate base of tongue cancers. PLoS One 2014; 9: e87565.
Ahuja AT, Ying M. Sonographic evaluation of cervical lymph nodes. AJR Am J Roentgenol 2005; 184: 1691-1699.
Sewnaik A, Keereweer S, Al-Mamgani A et al. High complication risk of salvage surgery after chemoradiation failures. Acta Otolaryngol 2012; 132: 96-100.
Zafereo ME, Hanasono MM, Rosenthal DI et al. The role of salvage surgery in patients with recurrent squamous cell carcinoma of the oropharynx. Cancer 2009; 115: 5723-5733.
de Mello RA, Gerós S, Alves MP et al. Cetuximab plus platinum-based chemotherapy in head and neck squamous cell carcinoma: a retrospective study in a single comprehensive European cancer institution. PLoS One 2014; 9: e86697.
Cacicedo J, Navarro A, Alongi F et al. The role of re-irradiation of secondary and recurrent head and neck carcinomas. Is it a potentially curative treatment? A practical approach. Cancer Treat Rev 2014; 40: 178-189.
Spencer SA, Harris J, Wheeler RH et al. Final report of RTOG 9610, a multi-institutional trial of reirradiation and chemotherapy for unresectable recurrent squamous cell carcinoma of the head and neck. Head Neck 2008; 30: 281-288.
Langer CJ, Harris J, Horwitz EM et al. Phase II study of low-dose paclitaxel and cisplatin in combination with split-course concomitant twice-daily reirradiation in recurrent squamous cell carcinoma of the head and neck: results of Radiation Therapy Oncology Group Protocol 9911. J Clin Oncol 2007; 25: 4800-4805.
Mazeron JJ, Ardiet JM, Haie-Meder C et al. GEC-ESTRO recommendations for brachytherapy for head and neck squamous cell carcinomas. Radiother Oncol 2009; 91: 150-156.
Hoebers F, Heemsbergen W, Moor S et al. Reirradiation for head-and-neck cancer: delicate balance between effectiveness and toxicity. Int J Radiat Oncol Biol Phys 2011; 81: e111-e118.
Puthawala A, Nisar SA, Gamie S et al. Interstitial low-dose-rate brachytherapy as a salvage treatment for recurrent head-and-neck cancers: long-term results. Int J Radiat Oncol Biol Phys 2001; 51: 354-362.
Langlois D, Hoffstetter S, Malissard L et al. Salvage irradiation of oropharynx and mobile tongue about 192 iridium brachytherapy in Centre Alexis Vautrin. Int J Radiat Oncol Biol Phys 1988; 14: 849-853.
Mazeron JJ, Langlois D, Glaubiger D et al. Salvage irradiation of oropharyngeal cancers using iridium 192 wire implants: 5-year results of 70 cases. Int J Radiat Oncol Biol Phys 1987; 13: 957-962.
Strnad V, Geiger M, Lotter M et al The role of pulsed-dose-rate brachytherapy in previously irradiated head-and-neck cancer. Brachytherapy 2003; 2: 158-163.
Ahuja A, Ying M. Grey-scale sonography in assessment of cervical lymphadenopathy: review of sonographic appearances and features that may help a beginner. Br J Oral Maxillofac Surg 2000; 38: 451-459.
 
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