Advances in Psychiatry and Neurology
eISSN: 2720-5371
ISSN: 1230-2813
Advances in Psychiatry and Neurology/Postępy Psychiatrii i Neurologii
Current issue Archive Manuscripts accepted About the journal Scientific board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Search
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

Without publication fees

without publication fees

Open access

without publication fees
4/2025
vol. 34
 
Share:
Send email
Share:
abstract:
Original article

From youth to late age: a comparative analysis of clinical and demographic profiles in multiple sclerosis by age at onset

Piotr T. Oleksy
1
,
Aleksandra Tobiasz
1
,
Magdalena Reclik
1
,
Ewa Góralczyk
1
,
Justyna Talaska
1
,
Zuzanna Szatkowska
1
,
Michalina Rzepka
2
,
Tomasz Chmiela
2
,
Weronika Galus
2
,
Joanna Siuda
2

  1. Students’ Scientific Association, Department of Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland
  2. Department of Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland
Adv Psychiatry Neurol 2025; 34 (4)
DOI: https://doi.org/10.5114/ppn.2025.156740
Online publish date: 2025/12/08
View full text Get citation
 
PlumX metrics:
Purpose
This study aimed to compare clinical and demographic characteristics, treatment approaches, and comorbidities among multiple sclerosis (MS) patients with pediatric-onset (POMS), adult-onset (AOMS), and late-onset multiple sclerosis (LOMS).

Methods
We analyzed the medical records of 439 patients diagnosed with MS, hospitalized between 2018 and 2023 in the University Clinical Center, Medical University of Silesia. The patients were divided into categories based on their age at onset: POMS – < 18 years, AOMS – 18-49 years, and LOMS – ≥ 50 years. Age of onset, symptoms, age at diagnosis, diagnostic delay, Expanded Disability Status Scale (EDSS) scores, course of the disease, relapse characteristics, comorbidities, and use of disease-modifying therapy were compared between the groups.

Results
The LOMS group was characterized by a higher proportion of males, had the longest diagnostic delay and disease duration, highest comorbidity rates, and a greater level of disability. Median EDSS score was highest in the LOMS group (3.16) and lowest in the POMS (0.73) (p < 0.001). Relapsing-remitting MS was most prevalent in the POMS and AOMS groups, while progressive MS was more prevalent in LOMS (p < 0.001). The longest first-line therapy durations and the lowest rate of switching to second-line therapies were observed in the LOMS group.

Conclusions
Characteristics of MS vary, based on the age of onset, hence every patient requires a personalized approach. The higher prevalence of the progressive form, more frequent comorbidities and higher degree of disability observed in the LOMS group makes treatment of this group more challenging and treatment switching is more frequent.

keywords:

multiple sclerosis, relapsing-remitting multiple sclerosis, age of onset, demyelinating autoimmune diseases, primary progressive multiple sclerosis
Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2025 Termedia Sp. z o.o.
Developed by Bentus.