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Folia Neuropathologica
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1/2022
vol. 60
 
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abstract:
Original paper

Iduna contributes to the therapeutic effect of DHA in a cell and mouse model of traumatic brain injury via Wnt/MDM2 pathway

Xinyu Shi
1
,
Fan Yang
1
,
Zhenyu Ge
2
,
Zongchun Tang
1
,
Kunhu Zhang
1
,
Bobo Chen
1
,
Hongbin Wang
1
,
Jian Hou
3
,
Hu Li
1
,
Zheng Tang
1

1.
Baoji High-tech Hospital, Baoji, Shaanxi, China
2.
Baoji Central Hospital, Baoji, Shaanxi, China
3.
Shanxi Provincial Corps Hospital of the CAPF, Taiyuan, Shanxi, China
Folia Neuropathol 2022; 60 (1): 92-104
DOI: https://doi.org/10.5114/fn.2021.112567
Online publish date: 2022/02/23
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Traumatic brain injury (TBI) is a severe condition that leads to brain damage and affects brain function. Importantly, TBI incurs public health costs due to its high mortality, and effective treatment for TBI is still lacking. Docosahexaenoic acid (DHA) has a neuroprotective effect that can reduce oxidative, apoptosis, and inflammatory processes. Administration of DHA after TBI attenuates oxidative stress and protein accumulation and is regarded as a potential therapeutic. Iduna is a regulator of parthanatos, and upregulation of Iduna reduces cellular damage and mitochondrial dysfunction. Thus, we speculated that overexpression of Iduna might promote DHA therapy in the treatment of TBI. Here, we found that after combination overexpression of Iduna and DHA in a mouse model of TBI, the expression of inflammatory factors was reduced, while the secretion of neuroprotective factors was increased. In addition, we found that these effects might be mediated by the Wnt/MDM2 pathway, and Iduna might be a therapeutic target for TBI.
keywords:

DHA, TBI, Iduna, inflammation, Wnt/MDM2
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