Folia Neuropathologica

Abstract

2/2022 vol. 60
Original paper

Immunolocalization of neurokinin 1 receptor in WHO grade 4 astrocytomas, oral squamous cell and urothelial carcinoma

Riffat Mehboob 1
,
Maher Kurdi 2
,
Saleh Baeesa 3
,
Taher Fawzy Halawa 4
,
Imrana Tanvir 2
,
Yazid Maghrabi 5
,
Sahar Hakamy 6
,
Rothaina Saeedi 3
,
Rana Moshref 7
,
Hisham Nasief 8
,
Amber Hassan 9
,
Humaira Waseem 10
,
Shahida Rasool 1
,
Basem Bahakeem 11
,
Eyad Faizo 12
,
Yousef Katib 13
,
Ahmed K. Bamaga 14, 15
,
Nashwa Aldardeir 16
  1. Lahore Medical Research Center, LLP, Lahore, Pakistan
  2. Department of Pathology, Faculty of Medicine in Rabigh, King Abdulaziz University, Saudi Arabia
  3. Division of Neurosurgery, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
  4. Department of Pediatrics, Rabigh Faculty of Medicine, King Abdulaziz University, Saudi Arabia
  5. Neurosciences Department, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia
  6. Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia
  7. Section of Neurosurgery, King Abdulaziz Medical City, Jeddah, Saudi Arabia
  8. Department of Obstetrics and Gynaecology, Faculty of Medicine, Jeddah, Saudi Arabia
  9. University of Milan, Milan, Italy
  10. Fatima Jinnah Medical University, Lahore, Pakistan
  11. Faculty of Medicine, Umm-Alqura University, Makkah, Saudi Arabia
  12. Division of Neurosurgery, Department of Surgery, Faculty of Medicine, Tabuk University, Tabuk, Saudi Arabia
  13. Department of Radiology, Faculty of Medicine, Taibah University, Al Madinah Al Munawwarah, Saudi Arabia
  14. Neurology Division, Paediatric Department, Faculty of Medicine, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah, Saudi Arabia
  15. Paediatric Department, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia
  16. Department of Obstetrics and Gynaecology, Faculty of Medicine, King Abdulaziz University, Saudi Arabia
Folia Neuropathol 2022; 60 (2): 165-176
DOI: https://doi.org/10.5114/fn.2022.116469
Online publish date: 2022/06/30
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Introduction

Neurokinin-1 receptor (NK-1R) induces inflammatory reactions in peripheral tissues but its regulatory effects in target tissues is dependent on receptor signalling. Substance P (SP) has a high affinity for the NK-1R, to which it binds preferentially. We aimed to investigate the expression of NK-1R in World Health Organization (WHO) grade 4 astrocytomas as well as in oral squamous cell carcinoma (OSCC) and urothelial carcinoma, and its association with disease progression.

Material and methods

The study included tissue samples from 19 brain astrocytomas, 40 OSCCs and 10 urothelial carcinomas. NK-1R expression was quantitatively assessed in the tumour cells using immunohistochemistry. The relationship between NK-1R expression in astrocytomas and recurrence-free interval has been explored.

Results

The results showed that the NK-1R was intensely expressed in patients with WHO grade 4 astrocytoma, OSCC and urothelial carcinoma. However, cases clinically diagnosed as a low-grade cancer showed reduced NK-1R expression.

Conclusions

NK-1R is overexpressed in all cases of WHO grade 4 astrocytoma, OSCC and urothelial carcinoma. The ubi­quitous presence of SP/NK-1R complex during tumour development and progression suggests a possible therapeutic key strategy to use NK-1R antagonist as an adjuvant therapy in the future.

Keywords

neurokinin-1 receptor, immunohistochemistry, substance P, immunolocalization, glioblastoma, oral squamous cell carcinoma, urothelial carcinoma

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