eISSN: 1509-572x
ISSN: 1641-4640
Folia Neuropathologica
Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
3/2022
vol. 60
 
Share:
Share:
abstract:
Review paper

Incidence and morphology of secondary TDP-43 proteinopathies: Part 1

Albert Acewicz
1
,
Tomasz Stępień
1
,
Paulina Felczak
1
,
Sylwia Tarka
2
,
Teresa Wierzba-Bobrowicz
1

  1. Department of Neuropathology, Institute of Psychiatry and Neurology, Warsaw, Poland
  2. Department of Forensic Medicine, Medical University of Warsaw, Warsaw, Poland
Folia Neuropathol 2022; 60 (3): 267-276
Online publish date: 2022/11/03
View full text Get citation
 
PlumX metrics:
Transactive response DNA binding protein of 43 kDa (TDP-43) is considered to play an essential role in the pathogenesis of frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Growing body of evidence indicate that pathological TDP-43 inclusions frequently occur in the context of other distinctive hallmark pathologies, referred to as secondary

TDP-43 proteinopathies. Comorbid TDP-43 pathology is well-documented in several neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, multiple system atrophy, or progressive supranuclear palsy. It may also appear as a consequence of less obvious disease etiologies, i.e. post-traumatic (chronic traumatic encephalopathy), neoplastic (pilocytic astrocytoma), or post-infectious (post-encephalitic parkinsonism). The aim of the present review was to evaluate the incidence, morphology, and role of TDP-43 pathology in the secondary TDP-43 proteinopathies. This article (Part 1) discussed TDP-43 pathology in more common neurodegenerative diseases, including Alzheimer’s disease, Lewy body disease, Huntington’s disease, multiple system atrophy, corticobasal degeneration, and progressive supranuclear palsy. A follow-up article (Part 2) will describe abnormal TDP-43 changes in rare neurodegenerative diseases or neurological diseases with nondegenerative etiology.
keywords:

TDP-43, pathology, proteinopathy, neurodegenerative, morphology, incidence, comorbidity

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.