eISSN: 1509-572x
ISSN: 1641-4640
Folia Neuropathologica
Current issue Archive Manuscripts accepted About the journal Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank
 
1/2022
vol. 60
 
Share:
Share:
more
 
 
abstract:
Original paper

Inhibition of poly (ADP-ribose) polymerase 1 in neuron cells might enhance the therapeutic effect of leonurine under cholesterol stimulation

Bo Hou
1
,
Zhigang Huan
2
,
Chao Zhang
3
,
Zhiyong Chen
4
,
Lingmei Ha
5
,
Shengxuan Huang
4

1.
Neurosurgery Department, Zibo First Hospital, Zibo, Shandong, China
2.
Neurology Department, Zibo First Hospital, Zibo, Shandong, China
3.
Neurosurgery Department, Tianjin Union Medical Center, China
4.
Neurosurgery Department, Sanming First Hospital Affiliated to Fujian Medical University, Sanming, Fujian, China
5.
Emergency Department, Characteristic Medical Center of PAP, Tianjin, China
Folia Neuropathol 2022; 60 (1): 76-91
Online publish date: 2022/03/29
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Atherosclerosis (AS) is a chronic inflammatory disease with high morbidity and mortality worldwide and is the pathologic basis of cerebral-cardiovascular disease. Cerebral infarction is caused by cerebral ischemia in the deep brain stem or cerebral hemisphere, and small vessel atherosclerosis is the pathophysiological basis of lacunar cerebral infarction. In this study, we found that inhibition of PARP1 in neuronal cells increased the proliferation rate of cells, reduced the concentration of cholesterol in neuronal cells, inhibited the expression and secretion of proinflammatory factors and promoted the expression and secretion of proangiogenic factors. In addition, the reverse transport process of cholesterol and autophagy process were activated in neuron cells by detecting the target proteins using western blotting analysis, and further experiments found that this process might be mediated by activation of the PI3K/AKT/mTOR signalling pathway. Thus, we thought inhibition of PARP1 might be a new therapeutic method for cerebral-cardiovascular disease.
keywords:

leonurine, cholesterol, neuron cell, PARP1, PI3K/AKT/mTOR

Quick links
© 2022 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.