Intracerebral hemorrhage in the context of cerebral amyloid angiopathy and varied time of onset of cerebral venous thrombosis: a case report

Tadeusz A. Mendel; Beata Błażejewska-Hyżorek; Grażyna M. Szpak; Tomasz Stępień; Eliza Lewandowska; Sylwia Tarka; Iwona Kurkowska-Jastrzębska; Teresa Wierzba-Bobrowicz

doi:10.5114/fn.2017.70490

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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3/2017
vol. 55

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abstract:

Case report

Intracerebral hemorrhage in the context of cerebral amyloid angiopathy and varied time of onset of cerebral venous thrombosis: a case report

Tadeusz A. Mendel

,

Beata Błażejewska-Hyżorek

,

Grażyna M. Szpak

,

Tomasz Stępień

,

Eliza Lewandowska

,

Sylwia Tarka

,

Iwona Kurkowska-Jastrzębska

,

Teresa Wierzba-Bobrowicz

Folia Neuropathol 2017; 55 (3): 242-248

DOI: https://doi.org/10.5114/fn.2017.70490

Online publish date: 2017/09/30

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AMA

Mendel T, Błażejewska-Hyżorek B, Szpak G, et al. Intracerebral hemorrhage in the context of cerebral amyloid angiopathy and varied time of onset of cerebral venous thrombosis: a case report. Folia Neuropathologica. 2017;55(3):242-248. doi:10.5114/fn.2017.70490.

APA

Mendel, T., Błażejewska-Hyżorek, B., Szpak, G., Stępień, T., Lewandowska, E.,  & Tarka, S. et al. (2017). Intracerebral hemorrhage in the context of cerebral amyloid angiopathy and varied time of onset of cerebral venous thrombosis: a case report. Folia Neuropathologica, 55(3), 242-248. https://doi.org/10.5114/fn.2017.70490

Chicago

Mendel, Tadeusz A., Beata Błażejewska-Hyżorek, Grażyna M. Szpak, Tomasz Stępień, Eliza Lewandowska, Sylwia Tarka,  and Iwona Kurkowska-Jastrzębska et al. 2017. "Intracerebral hemorrhage in the context of cerebral amyloid angiopathy and varied time of onset of cerebral venous thrombosis: a case report". Folia Neuropathologica 55 (3): 242-248. doi:10.5114/fn.2017.70490.

Harvard

Mendel, T., Błażejewska-Hyżorek, B., Szpak, G., Stępień, T., Lewandowska, E., Tarka, S., Kurkowska-Jastrzębska, I.,  and Wierzba-Bobrowicz, T. (2017). Intracerebral hemorrhage in the context of cerebral amyloid angiopathy and varied time of onset of cerebral venous thrombosis: a case report. Folia Neuropathologica, 55(3), pp.242-248. https://doi.org/10.5114/fn.2017.70490

MLA

Mendel, Tadeusz A. et al. "Intracerebral hemorrhage in the context of cerebral amyloid angiopathy and varied time of onset of cerebral venous thrombosis: a case report." Folia Neuropathologica, vol. 55, no. 3, 2017, pp. 242-248. doi:10.5114/fn.2017.70490.

Vancouver

Mendel T, Błażejewska-Hyżorek B, Szpak G, Stępień T, Lewandowska E, Tarka S et al. Intracerebral hemorrhage in the context of cerebral amyloid angiopathy and varied time of onset of cerebral venous thrombosis: a case report. Folia Neuropathologica. 2017;55(3):242-248. doi:10.5114/fn.2017.70490.

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In patients with cerebral venous thrombosis (CVT) the incidence of intracerebral hemorrhage (ICH) is estimated at about 37% and subarachnoid hemorrhage (SAH) at 1% of patients. A case with coincident occurrence of ICH, SAH and CVT in a patient with cerebral amyloid angiopathy (CAA) is reported.

A 79-year-old woman was admitted to the Neurological Department after the occurrence of generalized seizures, the first in her life. On admission she was unconscious with right hemiparesis and deviation of eyes to the left. On computed tomography (CT) scan many hemorrhagic infarcts were present in the frontal, parietal, temporal and left occipital lobes. Angio-CT revealed thrombosis in the right transverse sinus, right internal carotid vein and superior sagittal sinus. Her state slowly deteriorated. She died after 6 days. Neuropathologically, many hemorrhagic infarcts were observed in cortical regions in the vicinity of veins with thrombosis and in the white matter. The varied time of onset of thrombosis of the right sigmoid sinus, right superior petrosal sinus, superior sagittal sinus, right transverse sinus and the proximal part of the right internal carotid vein was confirmed. cerebral amyloid angiopathy in brain vessels was diagnosed.

Subarachnoid hemorrhage is a very uncommon presentation of CVT and may coexist with CAA. We can only speculate that CAA may have an effect on vein destruction and can promote cerebral vein thrombosis and in consequence also predispose to intracerebral hemorrhage and subarachnoid hemorrhage. The most probable cause of extensive thrombosis was a coagulation disorder.

keywords:

Intracerebral hemorrhage in the context of cerebral amyloid angiopathy and varied time of onset of cerebral venous thrombosis: a case report

Tadeusz A. Mendel , Beata Błażejewska-Hyżorek , Grażyna M. Szpak , Tomasz Stępień , Eliza Lewandowska , Sylwia Tarka , Iwona Kurkowska-Jastrzębska , Teresa Wierzba-Bobrowicz

cerebral amyloid angiopathy, cerebral venous thrombosis, intracerebral hemorrhage, β-amyloid

Tadeusz A. Mendel

,

Beata Błażejewska-Hyżorek

,

Grażyna M. Szpak

,

Tomasz Stępień

,

Eliza Lewandowska

,

Sylwia Tarka

,

Iwona Kurkowska-Jastrzębska

,

Teresa Wierzba-Bobrowicz