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Gastroenterology Review/Przegląd Gastroenterologiczny
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Local recurrence of sporadic mesenteric fibromatosis following radical surgery attacking the proximal jejunum

Selçuk Gülmez, Ebubekir Gündeş, Aziz Serkan Senger, Orhan Uzun, Ulaş Aday, Hüseyin Çiyiltepe, Durmuş Ali Çetin, Emre Bozdağ, Kamuran Cumhur Değer, Erdal Polat

Data publikacji online: 2017/09/30
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The term “desmoid” was first coined by Müller in 1838, having derived it from the Greek word “desmos,” meaning ligament or tendon [1]. Desmoid-type fibromatosis, also known as aggressive fibromatosis, is a rare mesenchymal tumour characterised by the over-multiplication of fibroblasts and myofibroblasts originating from the deep muscular fascia, aponeurosis, tendon, and scar tissue [2]. It accounts for about 0.03% of all tumours, while its rate is about 3% in all soft tissue tumours. Its annual incidence is 2–4 per million. Desmoid-type fibromatosis is seen more often in female patients aged between 10 and 40 years [3].
It histologically has a benign morphology, but it has been classified as “intermediate malign” due to its high rate of local recurrence because of the infiltration of neighbouring structures following radical surgery [4]. Although desmoid tumours have been characterised as aggressive with these characteristics, most of them grow slowly and do not metastasise [5].
A 48-year-old female patient presented with complaints of intermittent epigastric pain, nausea, and rarely vomiting. The patient, who had no previous history of abdominal surgery, had menstrual irregularities. Her family history revealed no malignity cases. There were no pathologies in her laboratory parameters other than iron deficiency anaemia. Her tumour markers were within normal values. The patient’s preoperative gastroscopy and colonoscopy results were normal. The abdominal computed tomography (CT) showed a heterogeneous solid mass of 9.5 × 8 × 7 cm in the upper abdomen middle part with smooth borders localised in the mesenteric bowel, closely neighbouring the transverse colon and intestinal loops, displacing them, but whose origin could not be clearly differentiated (Figure 1 A). Intraoperative findings included a mass invading the neighbouring omentum majus by surrounding the jejunal serosa originating from the jejunal mesentery at 10 cm distal from the Treitz (Figure 1 B). No additional intraabdominal pathologies and metastases were found. The 25 cm jejunum and the invaded omentum were resected in a block alongside the mass (Figure 1 C). End-to-end jejunojejunostomy was performed for intestinal continuity. The macroscopic analysis of the surgical piece revealed a circular, partly lobulated mass of 9.5 × 8 × 7 cm with smooth borders localised in the jejunal mesentery attacking the jejunal serosa, which had elastic consistency and a...

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Polat C, Aktepe F, Arikan Y, et al. A giant mesenteric fibromatosis case presenting with mechanical intestinal obstruction and successfully resected with partial duodeno-jejunectomy and right hemicolectomy. Clinics 2010; 65: 110-13.
Efthimiopoulos GA, Chatzifotiou D, Drogouti M, et al. Primary asymptomatic desmoid tumor of the mesentery. Am J Case Rep 2015; 16: 160-3.
Otero S, Moskovic EC, Strauss DC, et al. Desmoid-type fibromatosis. Clin Radiol 2015; 70: 1038-45.
Li Destri G, Ferraro MJ, Calabrini M, et al. Desmoid-type fibro­matosis of the mesentery: report of a sporadic case with emphasis on differential diagnostic problems. Case Rep Med 2014; 2014: 850180.
Stürmlin J, Banz V, Metzger J. Diagnosis and management of the intra-abdominal desmoids tumour. J Surg Case Rep 2012; 2012: 2.
Kasper B, Ströbel P, Hohenberger P. Desmoid tumors: clinical features and treatment options for advanced disease. Oncologist 2011; 16: 682-93.
Wronski M, Bogna ZW, Slodkowski M, et al. Mesenteric fibromatosis with intestinal involvement mimicking a gastrointestinal stromal tumour. Radiol Oncol 2011; 45: 59-63.
Kotiligam D, Lazar AJF, Pollock RE, et al. Desmoid tumor: a disease opportune for molecular insights. Histol Histopathol 2008; 23: 117-26.
Wheeler M, Mercer D, Grant W, et al. Surgical treatment of intra-abdominal desmoid tumors resulting in short bowel syndrome. Cancers 2012; 4: 31-8.
Church J, Lynch C, Neary P, et al. A desmoid tumor-staging system separates patients with intra-abdominal, familial adenomatous polyposis-associated desmoid disease by behavior and prognosis. Dis Colon Rectum 2008; 51: 897-901.
Levy AD, Rimola J, Mehrotra AK, et al. From the archives of the AFIP: benign fibrous tumors and tumorlike lesions of the mesentery: radiologic-pathologic correlation. Radiographics 2006; 26: 245-64.
Wheeler M, Mercer D, Grant W, et al. Surgical treatment of intra-abdominal desmoid tumors resulting in short bowel syndrome. Cancers 2012; 4: 31-8.
Salas S, Dufresne A, Bui B, et al. Prognostic factors influencing progression-free survival determined from a series of sporadic desmoid tumors: a wait-and-see policy according to tumor presentation. J Clin Oncol 2011; 29: 3553-8.
Janinis J, Patriki M, Vini L, et al. The pharmacological treatment of aggressive fibromatosis: a systematic review. Ann Oncol 2003; 14: 181-90.
Koh PK, Loi C, Cao X, et al. Mesenteric desmoid tumors in Singapore familial adenomatous polyposis patients: clinical course and genetic profile in a predominantly Chinese population. Dis Colon Rectum 2007; 50: 75-82.
Church J, Berk T, Boman BM, et al. Collaborative Group of the Americas on Inherited Colorectal Cancer. Staging intra-abdominal desmoid tumors in familial adenomatous polyposis: a search for auniform approach to a troubling disease. Dis Colon Rectum 2005; 48: 1528-34.
Stoidis CN, Spyropoulos BG, Misiakos EP, et al. Surgical treatment of giant mesenteric fibromatosis presenting as a gastrointestinal stromal tumor: a case report. J Med Case Rep 2010; 4: 314.
Kasper B, Ströbel P, Hohenberger P. Desmoid tumors: clinical features and treatment options for advanced disease. Oncologist 2011; 16: 682-93.
Gari MK, Guraya SY, Hussein AM, et al. Giant mesenteric fibromatosis: report of a case and review of the literature. World J Gastrointest Surg 2012; 4: 79-82.
Ballo MT, Zagars GK, Pollack A, et al. Desmoid tumor: prognostic factors and outcome after surgery, radiation therapy, or combined surgery and radiation therapy. J Clin Oncol 1999; 17: 158-7.
Mendenhall WM, Zlotecki RA, Morris CG, et al. Aggressive fibro­matosis. Am J Clin Oncol 2005; 28: 211-5.
Nuyttens JJ, Rust PF, Thomas CR, et al. Surgery versus radiation therapy for patients with agressive fibromatosis or desmoid tumors: a comparative review of 22 articles. Cancer 2000; 88: 1517-23.
Bertagnolli MM, Morgan JA, Fletcher CD, et al. Multimodality treatment of mesenteric desmoid tumours. Eur J Cancer 2008; 44: 2404-10.
Wcislo G, Szarlej-Wcislo K, Szczylik C. Control of aggressive fibromatosis by treatment with imatinib mesylate. A case report and review of the literature. J Cancer Res Clin Oncol 2007; 133: 533-8.
Gounder MM, Lefkowitz RA, Keohan ML, et al. Activity of sorafenib against desmoid tumor/deep fibromatosis. Clin Cancer Res 2011; 17: 4082-90.
Fiore M, Rimareix F, Mariani L, et al. Desmoid-type fibromatosis: a front-line conservative approach to select patients for surgical treatment. Ann Surg Oncol 2009; 16: 2587-93.
Mullen JT, Delaney TF, Kobayashi WK, et al. Desmoid tumor: analysis of prognostic factors and outcomes in a surgical series. Ann Surg Oncol 2012; 19: 4028-35.
Colombo C, Miceli R, Lazar AJ, et al. CTNNB1 45F mutation is a molecular prognosticator of increased postoperative primary desmoid tumor recurrence: an independent, multicenter validation study. Cancer 2013; 119: 3696-702.
Kasper B, Baumgarten C, Bonvalot S, et al. Management of sporadic desmoid-type fibromatosis: a European consensus approach based on patients’ and professionals’ expertiseda sarcoma patients EuroNet and European Organisation for Research and Treatment of Cancer/Soft Tissue and Bone Sarcoma Group. Eur J Cancer 2015; 51: 127-36.
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