Medullary colonic carcinoma with microsatellite instability has lower survival compared with conventional colonic adenocarcinoma with microsatellite instability

Miguel A. Gómez-Álvarez; Leonardo S. Lino-Silva; Rosa A. Salcedo-Hernández; Alejandro Padilla-Rosciano; Erika B. Ruiz-García; Horacio N. López-Basave; German Calderillo-Ruiz; José M. Aguilar-Romero; Jorge A. Domínguez-Rodríguez; Ángel Herrera-Gómez; Abelardo Meneses-García

doi:10.5114/pg.2016.64740

eISSN: 1897-4317
ISSN: 1895-5770

Gastroenterology Review/Przegląd Gastroenterologiczny

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abstract:

Original paper

Medullary colonic carcinoma with microsatellite instability has lower survival compared with conventional colonic adenocarcinoma with microsatellite instability

Miguel A. Gómez-Álvarez

,

Leonardo S. Lino-Silva

,

Rosa A. Salcedo-Hernández

,

Alejandro Padilla-Rosciano

,

Erika B. Ruiz-García

,

Horacio N. López-Basave

,

German Calderillo-Ruiz

,

José M. Aguilar-Romero

,

Jorge A. Domínguez-Rodríguez

,

Ángel Herrera-Gómez

,

Abelardo Meneses-García

Gastroenterology Rev 2017; 12 (3): 208–214

DOI: https://doi.org/10.5114/pg.2016.64740

Online publish date: 2016/12/20

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AMA

Gómez-Álvarez M, Lino-Silva L, Salcedo-Hernández R, et al. Medullary colonic carcinoma with microsatellite instability has lower survival compared with conventional colonic adenocarcinoma with microsatellite instability. Gastroenterology Review/Przegląd Gastroenterologiczny. 2017;12(3):208-214. doi:10.5114/pg.2016.64740.

APA

Gómez-Álvarez, M., Lino-Silva, L., Salcedo-Hernández, R., Padilla-Rosciano, A., Ruiz-García, E.,  & López-Basave, H. et al. (2017). Medullary colonic carcinoma with microsatellite instability has lower survival compared with conventional colonic adenocarcinoma with microsatellite instability. Gastroenterology Review/Przegląd Gastroenterologiczny, 12(3), 208-214. https://doi.org/10.5114/pg.2016.64740

Chicago

Gómez-Álvarez, Miguel A., Leonardo S. Lino-Silva, Rosa A. Salcedo-Hernández, Alejandro Padilla-Rosciano, Erika B. Ruiz-García, Horacio N. López-Basave,  and German Calderillo-Ruiz et al. 2017. "Medullary colonic carcinoma with microsatellite instability has lower survival compared with conventional colonic adenocarcinoma with microsatellite instability". Gastroenterology Review/Przegląd Gastroenterologiczny 12 (3): 208-214. doi:10.5114/pg.2016.64740.

Harvard

Gómez-Álvarez, M., Lino-Silva, L., Salcedo-Hernández, R., Padilla-Rosciano, A., Ruiz-García, E., López-Basave, H., Calderillo-Ruiz, G., Aguilar-Romero, J., Domínguez-Rodríguez, J., Herrera-Gómez, Á.,  and Meneses-García, A. (2017). Medullary colonic carcinoma with microsatellite instability has lower survival compared with conventional colonic adenocarcinoma with microsatellite instability. Gastroenterology Review/Przegląd Gastroenterologiczny, 12(3), pp.208-214. https://doi.org/10.5114/pg.2016.64740

MLA

Gómez-Álvarez, Miguel A. et al. "Medullary colonic carcinoma with microsatellite instability has lower survival compared with conventional colonic adenocarcinoma with microsatellite instability." Gastroenterology Review/Przegląd Gastroenterologiczny, vol. 12, no. 3, 2017, pp. 208-214. doi:10.5114/pg.2016.64740.

Vancouver

Gómez-Álvarez M, Lino-Silva L, Salcedo-Hernández R, Padilla-Rosciano A, Ruiz-García E, López-Basave H et al. Medullary colonic carcinoma with microsatellite instability has lower survival compared with conventional colonic adenocarcinoma with microsatellite instability. Gastroenterology Review/Przegląd Gastroenterologiczny. 2017;12(3):208-214. doi:10.5114/pg.2016.64740.

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Introduction: Colorectal medullary carcinoma (MC) is a rare subtype of poorly differentiated adenocarcinoma (PDA) with unclear prognostic significance. Microsatellite instable (MSI) colorectal carcinomas have demonstrated better prognosis in clinical stage II.

Aim: To analyze the survival and clinicopathological characteristics of MCs versus PDAs with MSI in clinical stage III.

Material and methods: We studied 22 cases of PDAs with MSI versus 10 MCs.

Results: Of the 10 MCs, 7 patients were men; the mean age was 57.8 ±5.6 years. The mean tumor size was 9.6 ±4.1 cm, and the primary site was the right colon in 9; 7 patients showed lymph node metastases (LNM) and lymphovascular invasion (LVI). Of the 22 PDA cases, 12 (54.5%) were women with a mean age of 75 ±16.1 years. The mean tumor size was 6.4 ±3.2 cm. Twelve (54.5%) presented in the right colon, 21 (95.5%) showed LNM and 7 (31.8%) LVI. Follow-up was 32 ±8 months, with a 5-year overall survival of 42.9% for MCs and 76.6% for PDAs (p = 0.048). Univariate analysis found local recurrence (p = 0.001) and medullary subtype (p = 0.043) associated with lower survival.

Conclusions: Medullary carcinomas were of greater tumor size and associated with more LVI and worse survival versus PDAs with MSI in stage III.

keywords:

Medullary colonic carcinoma with microsatellite instability has lower survival compared with conventional colonic adenocarcinoma with microsatellite instability

Miguel A. Gómez-Álvarez , Leonardo S. Lino-Silva , Rosa A. Salcedo-Hernández , Alejandro Padilla-Rosciano , Erika B. Ruiz-García , Horacio N. López-Basave , German Calderillo-Ruiz , José M. Aguilar-Romero , Jorge A. Domínguez-Rodríguez , Ángel Herrera-Gómez , Abelardo Meneses-García

colorectal, cancer, microsatellite instability, medullary carcinoma, survival