eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
Current issue Archive Manuscripts accepted About the journal Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank
3/2020
vol. 45
 
Share:
Share:
more
 
 
abstract:
Clinical immunology

Natural killer frequency determines natural killer cytotoxicity directly in accentuated zones and indirectly in “moderate-to-normal frequency” segment

Boris V. Dons’koi
1
,
Victor P. Chernyshov
1
,
Dariia V. Osypchuk
1
,
Iryna O. Sudoma
2
,
Kseniia G. Khazhylenko
3
,
Galina V. Strelko
4
,
Wera J. Sirenko
5

1.
Institute of Pediatrics, Obstetrics and Gynecology, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
2.
NADIYA Clinic, Kyiv, Ukraine
3.
Isida-IVF, Kyiv, Ukraine
4.
IVMED Fertility Centre, Kyiv, Ukraine
5.
Institute for Reproductive Medicine-IVF, Kyiv, Ukraine
Cent Eur J Immunol 2020; 45 (3): 315-324
Online publish date: 2020/11/01
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Natural killer (NK) frequency and NK cytotoxicity (NKc) are key determining factors of a clinical outcome. In our previous study, we showed the prognostic clinical significance of immune parameters when they are beyond the optimal range (accentuated). In this study, we attempted to explain the disparity of accentuated but physiologically and immunologically normal NK parameters that might serve as negative clinical prognostics indications of failed pregnancies. We have analyzed NK%, NKc levels, and their reciprocal correlation in 2,804 patients with reproductive failures.

In the entire clinical population, NK% correlates with NKc. Interestingly, we found this relationship to be strongly dependent on NK level’s status. NK%-NKc correlation was the strongest (r = 0.2021, p < 0.0001) in a patient group with high NK% (> 17.5%). Patients with NK% between 15-17.5% manifested lower but still significant correlation NK%-NKc (r = 0.1213, p = 0.0155). Additionally, significant correlation (r = 0.2689, p < < 0.0001) between NK% and NKc was observed in a group of patients with NK levels < 7% (1.7-7%). While patients’ groups with NK% (7-15%) did not reveal NK%-NKc association.

This led us to hypothesize that the qualitative-quantitative status of NK population is responsible for their cytotoxic activity. Consistent with our hypothesis, the “balanced zone” NK% is tightly controlled, and thus does not correlate directly with NKc. In contrast, the “accentuated zones” of NK% escape this control and directly affecting NKc. Demonstrated phenomena supports our idea about the clinical significance of immune accentuation and explains its novel physiological role.
keywords:

NK cell cytotoxicity, NK cells, immune regulation

Quick links
© 2021 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe