eISSN: 1509-572x
ISSN: 1641-4640
Folia Neuropathologica
Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
vol. 43

Original article
A quantitative analysis of optic nerve axons in elderly control subjects and patients with Alzheimer’s disease

Anila B. Syed
Christopher U.M. Smith
Richard A. Armstrong

Folia Neuropathol. 2005; 43 (1): 1-6
Online publish date: 2005/03/23
View full text Get citation
Objective: To study the density and cross-sectional area of axons in the optic nerve in elderly control subjects and in cases of Alzheimer’s disease (AD) using an image analysis system.
Methods: Sections of optic nerves from control and AD patients were stained with toluidine blue to reveal axon profiles.
Results: The density of axons was reduced in both the center and peripheral portions of the optic nerve in AD compared with control patients. Analysis of axons with different cross-sectional areas suggested a specific loss of the smaller sized axons in AD, i.e., those with areas less that 1.99 µm2. An analysis of axons >11 µm2 in cross-sectional area suggested no specific loss of the larger axons in this group of patients.
Conclusions: The data suggest that image analysis provides an accurate and reproducible method of quantifying axons in the optic nerve. In addition, the data suggest that axons are lost throughout the optic nerve with a specific loss of the smaller-sized axons. Loss of the smaller axons may explain the deficits in color vision observed in a significant proportion of patients with AD.

Alzheimer’s disease, optic nerve, axons, size distribution, image analysis

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.