Original article<br>Suppression of the lipid peroxidation process in the CNS reduces neurological expression of experimentally induced autoimmune encephalomyelitis

Srdjan Ljubisavljevic; Ivana Stojanovic; Dusica Pavlovic; Maja Milojkovic; Dusan Sokolovic; Ivana Stevanovic; Aleksandar Petrovic

doi:10.5114/fn.2013.34196

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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abstract:

Original article
Suppression of the lipid peroxidation process in the CNS reduces neurological expression of experimentally induced autoimmune encephalomyelitis

Srdjan Ljubisavljevic

,

Ivana Stojanovic

,

Dusica Pavlovic

,

Maja Milojkovic

,

Dusan Sokolovic

,

Ivana Stevanovic

,

Aleksandar Petrovic

Folia Neuropathol 2013; 51 (1): 51-57

DOI: https://doi.org/10.5114/fn.2013.34196

Online publish date: 2013/03/28

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AMA

Ljubisavljevic S, Stojanovic I, Pavlovic D, et al. Original articleSuppression of the lipid peroxidation process in the CNS reduces neurological expression of experimentally induced autoimmune encephalomyelitis. Folia Neuropathologica. 2013;51(1):51-57. doi:10.5114/fn.2013.34196.

APA

Ljubisavljevic, S., Stojanovic, I., Pavlovic, D., Milojkovic, M., Sokolovic, D.,  & Stevanovic, I. et al. (2013). Original articleSuppression of the lipid peroxidation process in the CNS reduces neurological expression of experimentally induced autoimmune encephalomyelitis. Folia Neuropathologica, 51(1), 51-57. https://doi.org/10.5114/fn.2013.34196

Chicago

Ljubisavljevic, Srdjan, Ivana Stojanovic, Dusica Pavlovic, Maja Milojkovic, Dusan Sokolovic, Ivana Stevanovic,  and Aleksandar Petrovic. 2013. "Original articleSuppression of the lipid peroxidation process in the CNS reduces neurological expression of experimentally induced autoimmune encephalomyelitis". Folia Neuropathologica 51 (1): 51-57. doi:10.5114/fn.2013.34196.

Harvard

Ljubisavljevic, S., Stojanovic, I., Pavlovic, D., Milojkovic, M., Sokolovic, D., Stevanovic, I.,  and Petrovic, A. (2013). Original articleSuppression of the lipid peroxidation process in the CNS reduces neurological expression of experimentally induced autoimmune encephalomyelitis. Folia Neuropathologica, 51(1), pp.51-57. https://doi.org/10.5114/fn.2013.34196

MLA

Ljubisavljevic, Srdjan et al. "Original articleSuppression of the lipid peroxidation process in the CNS reduces neurological expression of experimentally induced autoimmune encephalomyelitis." Folia Neuropathologica, vol. 51, no. 1, 2013, pp. 51-57. doi:10.5114/fn.2013.34196.

Vancouver

Ljubisavljevic S, Stojanovic I, Pavlovic D, Milojkovic M, Sokolovic D, Stevanovic I et al. Original articleSuppression of the lipid peroxidation process in the CNS reduces neurological expression of experimentally induced autoimmune encephalomyelitis. Folia Neuropathologica. 2013;51(1):51-57. doi:10.5114/fn.2013.34196.

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Objective: Here we report the influence of malondialdehyde (MDA) as a measure of the lipid peroxidation process (LP), on multiple sclerosis (MS) pathogenesis and its neurological signs, during the treatment with aminoguanidine (AG) – a selective inducible nitric oxide synthase inhibitor and N-Acetyl cysteine (NAC) – an oxidative scavenger, in the experimental autoimmune encephalomyelitis (EAE), an animal model for studying MS.

Material and methods: Encephalomyelitis induction by the subcutaneous injection of myelin basic protein of bovine type, dissolved in phosphate buffered saline (PBS) emulsified in equal volume of the complete Freund’s adjuvant (CFA), was described in detail in our earlier published papers. Each of animals was randomly assigned to seven groups – control (PBS), EAE, CFA, EAE + AG, AG, EAE + NAC and NAC group. In each animal, the development of neurological signs of EAE was scored, these results were published earlier. MDA was evaluated in the central nervous system (CNS) structure – cerebellums and spinal cords.

Results: The obtained results show that the AG and NAC treatment significantly reduces the MDA level in both examined tissues (p < 0.05) ameliorating at the same time EAE clinical signs (p < 0.05).

Conclusions: Taking together our present and earlier findings we conclude that LP may provoke and promote MS, while blocking of this process results in amelioration of the clinical onset and disease activity. These results may be useful as a new insight into mechanisms and potential targets for therapeutic strategies in MS.

keywords:

Original articleSuppression of the lipid peroxidation process in the CNS reduces neurological expression of experimentally induced autoimmune encephalomyelitis

Srdjan Ljubisavljevic , Ivana Stojanovic , Dusica Pavlovic , Maja Milojkovic , Dusan Sokolovic , Ivana Stevanovic , Aleksandar Petrovic

malondialdehyde, lipid peroxidation, EAE, aminoguanidine, N-acetyl cysteine

Original article
Suppression of the lipid peroxidation process in the CNS reduces neurological expression of experimentally induced autoimmune encephalomyelitis

Srdjan Ljubisavljevic

,

Ivana Stojanovic

,

Dusica Pavlovic

,

Maja Milojkovic

,

Dusan Sokolovic

,

Ivana Stevanovic

,

Aleksandar Petrovic