Osteoprotegerin, receptor activator of nuclear factor kB and receptor activator of nuclear factor κB ligand and bone mineralization in children with inflammatory bowel diseases

Agnieszka Jankowska; Anna Korzon-Burakowska; Barbara Kamińska

doi:10.5114/pg.2011.24303

eISSN: 1897-4317
ISSN: 1895-5770

Gastroenterology Review/Przegląd Gastroenterologiczny

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4/2011
vol. 6

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abstract:

Review paper

Osteoprotegerin, receptor activator of nuclear factor kB and receptor activator of nuclear factor κB ligand and bone mineralization in children with inflammatory bowel diseases

Agnieszka Jankowska

,

Anna Korzon-Burakowska

,

Barbara Kamińska

Przegląd Gastroenterologiczny 2011; 6 (4): 213–217

DOI: https://doi.org/10.5114/pg.2011.24303

Online publish date: 2011/09/06

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AMA

Jankowska A, Korzon-Burakowska A, Kamińska B. Osteoprotegerin, receptor activator of nuclear factor kB and receptor activator of nuclear factor κB ligand and bone mineralization in children with inflammatory bowel diseases. Gastroenterology Review/Przegląd Gastroenterologiczny. 2011;6(4):213-217. doi:10.5114/pg.2011.24303.

APA

Jankowska, A., Korzon-Burakowska, A.,  & Kamińska, B. (2011). Osteoprotegerin, receptor activator of nuclear factor kB and receptor activator of nuclear factor κB ligand and bone mineralization in children with inflammatory bowel diseases. Gastroenterology Review/Przegląd Gastroenterologiczny, 6(4), 213-217. https://doi.org/10.5114/pg.2011.24303

Chicago

Jankowska, Agnieszka, Anna Korzon-Burakowska,  and Barbara Kamińska. 2011. "Osteoprotegerin, receptor activator of nuclear factor kB and receptor activator of nuclear factor κB ligand and bone mineralization in children with inflammatory bowel diseases". Gastroenterology Review/Przegląd Gastroenterologiczny 6 (4): 213-217. doi:10.5114/pg.2011.24303.

Harvard

Jankowska, A., Korzon-Burakowska, A.,  and Kamińska, B. (2011). Osteoprotegerin, receptor activator of nuclear factor kB and receptor activator of nuclear factor κB ligand and bone mineralization in children with inflammatory bowel diseases. Gastroenterology Review/Przegląd Gastroenterologiczny, 6(4), pp.213-217. https://doi.org/10.5114/pg.2011.24303

MLA

Jankowska, Agnieszka et al. "Osteoprotegerin, receptor activator of nuclear factor kB and receptor activator of nuclear factor κB ligand and bone mineralization in children with inflammatory bowel diseases." Gastroenterology Review/Przegląd Gastroenterologiczny, vol. 6, no. 4, 2011, pp. 213-217. doi:10.5114/pg.2011.24303.

Vancouver

Jankowska A, Korzon-Burakowska A, Kamińska B. Osteoprotegerin, receptor activator of nuclear factor kB and receptor activator of nuclear factor κB ligand and bone mineralization in children with inflammatory bowel diseases. Gastroenterology Review/Przegląd Gastroenterologiczny. 2011;6(4):213-217. doi:10.5114/pg.2011.24303.

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Morbidity of inflammatory bowel diseases (IBD) has been increasing in children recently. The pathogenesis of these autoimmune diseases still remains unknown, so the therapy of IBD is mainly symptomatic. Chronic inflammation and applied treatment involve many complications, among which impaired bone mineralization is quite common. Great expectations arose when three cytokines were explored: osteoprotegerin (OPG), receptor activator of nuclear factor kB (RANK) and receptor activator of nuclear factor κB ligand (RANKL). These molecules were identified in many cells and play a key role in bone formation and resorption, as well as in the immune system. Due to increasing knowledge about these cytokines there are new possibilities for treatment of the diseases in which OPG, RANK and RANKL are engaged.

keywords:

Osteoprotegerin, receptor activator of nuclear factor kB and receptor activator of nuclear factor κB ligand and bone mineralization in children with inflammatory bowel diseases

Agnieszka Jankowska , Anna Korzon-Burakowska , Barbara Kamińska

inflammatory bowel diseases, osteoprotegerin, children

Agnieszka Jankowska

,

Anna Korzon-Burakowska

,

Barbara Kamińska