Abstract
Patterns and grades of presentation of colon cancer in Northern Saudi Arabia
- Department of Internal Medicine, Al Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia
- Department of Pathology, College of Medicine, University of Ha’il, Saudi Arabia
- Department of Histopathology and Cytology, FMLS, University of Khartoum, Sudan
Introduction
To determine the patterns and grades of colon cancer presentation in Northern Saudi Arabia.
Material and methods
Retrieved data and tissue blocks related to 50 colorectal patients from King Khalid Hospital, Hai’l province, Northern Saudi Arabia were used. The sample represented all available colorectal specimens (full coverage of cancer cases within 10 years). The retrieved data included a full histopathology report, gender, and age. All tissues were retrieved in the form of formalin-fixed paraffin wax processed blocks. The tissues were found to be obtained in the form of colonoscopy or/and biopsy.
Results
The diagnosed colon cancers included conventional adenocarcinoma 36 (72%), mucinous adenocarcinoma 4 (8%), carcinoma-in-situ 4 (8%), and invasive adenocarcinoma 6 (12%). Moderately differentiated and poorly differentiated stages were confirmed in 46 (92%) and 4 (8%), respectively.
Conclusions
Conventional adenocarcinoma is the most common presenting colon cancer at and relatively younger age. Mucinous adenocarcinoma is frequently presented in female patients of a somewhat more youthful generation. Most patients are diagnosed with moderately differentiated adenocarcinoma, followed by poorly differentiated adenocarcinoma. The findings necessitate the urgent intervention of national policies for early detection by implementing sustainable screening programs.
Keywords
colon cancer, colorectal adenocarcinoma, mucinous adenocarcinoma, Saudi Arabia
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