Pediatric Endocrinology Diabetes and Metabolism

Predyktory jatrogennej niewydolności nadnerczy u dzieci – roczna analiza prospektywna

Marwa Abdelbari 1, 2
,
Bel Hadj Ali Wiem 1
,
Ach Taieb 2, 3, 4
,
Tej Amel 1, 2
,
Jaballah Nessrine 1, 2
,
Soyah Najla 1, 2
,
Bouguila Jihene 1, 2
,
Zaouali Monia 4
,
Kebaili Raoudha 1, 2
,
Boughamoura Lamia 1, 2

  1. Department of Paediatrics, Farhat Hached University Hospital, Sousse, Tunisia

  2. Faculty of Medicine of Sousse, University of Sousse, Tunisia

  3. Department of Endocrinology, Farhat Hached University Hospital, Sousse, Tunisia

  4. Laboratory of Physiology and Hormonal Exploration, LR 19 ES 09, Farhat Hached University Hospital, Sousse, Tunisia

DOI: https://doi.org/10.5114/pedm.2026.165312
Data publikacji online: 2026/10/15
Plik artykułu
00465_Predictors.pdf
  1. Prete A, Bancos I. Glucocorticoid induced adrenal insufficiency. BMJ 2021; 374: n1380. doi: 10.1136/bmj.n1380.
  2. Broersen LHA, Pereira AM, Jørgensen JOL, Dekkers OM. Adrenal insufficiency in corticosteroids use: systematic review and meta-analysis. J Clin Endocrinol Metab 2015; 100: 2171–2180. doi: 10.1210/jc.2015-1218.
  3. Einaudi MA, Lequin MH, de Rijke YB, et al. Adrenal axis function after high-dose steroid therapy for childhood acute lymphoblastic leukemia. Pediatr Blood Cancer 2008; 50: 537–541. doi: 10.1002/pbc.21339.
  4. Lipworth BJ, Jackson CM. Effects of oral and inhaled corticosteroids on the hypothalamic-pituitary-adrenal axis. J Allergy Clin Immunol 1999; 104: 713–714. doi: 10.1016/s0091-6749(99)70352-0.
  5. Ospina NS, Al Nofal A, Bancos I, et al. ACTH stimulation tests for the diagnosis of adrenal insufficiency: systematic review and meta-analysis. J Clin Endocrinol Metab 2016; 101: 427–434. doi: 10.1210/jc.2015-1700.
  6. Beuschlein F, Else T, Bancos I, et al. European Society of Endocrinology and Endocrine Society Joint Clinical Guideline: Diagnosis and therapy of glucocorticoid-induced adrenal insufficiency. Eur J Endocrinol 2024; 190: G25–G51. doi: 10.1093/ejendo/lvae029.
  7. Global Initiative for Asthma. Pocket guide for asthma management and prevention, 2023. Global Initiative for Asthma; 2023. Available at: https://www.ginasthma.org (accessed 8 Jul 2026).
  8. Kokron CM, Castro AS, Solé D, Naspitz CK. Lysine-vasopressin in the evaluation of the hypothalamic-pituitary-adrenal axis in children with allergic rhinitis treated with intranasal beclomethasone dipropionate or oral prednisone. J Investig Allergol Clin Immunol 1997; 7: 51–56.
  9. Price J, Lenney W, Duncan C, et al. HPA-axis effects of nebulised fluticasone propionate compared with oral prednisolone in childhood asthma. Respir Med 2002; 96: 625–631. doi: 10.1053/rmed.2002.1323.
  10. Laulhé M, Dumaine C, Chevenne D, et al. Glucocorticoid induced adrenal insufficiency in children: morning cortisol values to avoid LDSST. Front Pediatr 2022; 10: 981765. doi: 10.3389/fped.2022.981765.
  11. Wildi-Runge S, Deladoëy J, Bélanger C, et al. A search for variables predicting cortisol response to low-dose corticotropin stimulation following supraphysiological doses of glucocorticoids. J Pediatr 2013; 163: 484–488. doi: 10.1016/j.jpeds.2013.01.011.
  12. Zöllner EW, Lombard CJ, Galal U, et al. Hypothalamic-pituitary-adrenal axis suppression in asthmatic school children. Pediatrics 2012; 130: e1512–e1519. doi: 10.1542/peds.2012-1147.
  13. Gordijn MS, Gemke RJBJ, van Dalen EC, et al. Hypothalamic-pituitary-adrenal (HPA) axis suppression after treatment with glucocorticoid therapy for childhood acute lymphoblastic leukaemia. Cochrane Database Syst Rev 2012; 16: CD008727. doi: 10.1002/14651858.CD008727.pub2.
  14. Goldbloom EB, Mokashi A, Cummings EA, et al. Symptomatic adrenal suppression among children in Canada. Arch Dis Child 2017; 102: 338–339. doi: 10.1136/archdischild-2016-311223.
  15. Nielsen LP, Dahl R. Therapeutic ratio of inhaled corticosteroids in adult asthma. Am J Respir Crit Care Med 2000; 162: 2053–2057. doi: 10.1164/ajrccm.162.6.9912072.
  16. Grove A, Allam C, McFarlane L, et al. A comparison of the systemic bioactivity of inhaled budesonide and fluticasone propionate in normal subjects. Br J Clin Pharmacol 1994; 38: 527–532. doi: 10.1111/j.1365-2125.1994.tb04394.x.
  17. Li JT, Goldstein MF, Gross GN, et al. Effects of fluticasone propionate, triamcinolone acetonide, prednisone, and placebo on the hypothalamic-pituitary-adrenal axis. J Allergy Clin Immunol 1999; 103: 622–629. doi: 10.1016/s0091-6749(99)70234-4.
  18. Todd GRG, Acerini CL, Ross-Russell R, et al. Survey of adrenal crisis associated with inhaled corticosteroids in the United Kingdom. Arch Dis Child 2002; 87: 457–461. doi: 10.1136/adc.87.6.457.
  19. Smith RW, Downey K, Gordon M, et al. Prevalence of hypothalamic-pituitary-adrenal axis suppression in children treated for asthma with inhaled corticosteroid. Paediatr Child Health 2012; 17: e34–e39. doi: 10.1093/pch/17.5.e34.
  20. Lötvall J, Bleecker ER, Busse WW, et al. Efficacy and safety of fluticasone furoate 100 µg once-daily in patients with persistent asthma: a 24-week placebo and active-controlled randomised trial. Respir Med 2014; 108: 41–49. doi: 10.1016/j.rmed.2013.11.009.
  21. Aljebab F, Choonara I, Conroy S. Systematic review of the toxicity of short-course oral corticosteroids in children. Arch Dis Child 2016; 101: 365–370. doi: 10.1136/archdischild-2015-309522.
  22. Broide J, Soferman R, Kivity S, et al. Low-dose adrenocorticotropin test reveals impaired adrenal function in patients taking inhaled corticosteroids. J Clin Endocrinol Metab 1995; 80: 1243–1246. doi: 10.1210/jcem.80.4.7714095.
  23. Kazlauskaite R, Maghnie M. Pitfalls in the diagnosis of central adrenal insufficiency in children. Endocr Dev 2010; 17: 96–110. doi: 10.1159/000262532.
ZGŁASZANIE PRAC
Udostępnij
without publication fees
Zintergrowane z
integrated with publons
Zasady redakcyjne
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications