Pregabalin and duloxetine in the treatment of neuropathic pain – why the use of off-label drugs is consistent with the standards of management and current medical knowledge

Jarosław Woroń

eISSN: 2450-4459
ISSN: 2450-3517

Lekarz POZ

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1/2020
vol. 6

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abstract:

Review article

Pregabalin and duloxetine in the treatment of neuropathic pain – why the use of off-label drugs is consistent with the standards of management and current medical knowledge

Jarosław Woroń

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Kliniczny Oddział Anestezjologii i Intensywnej Terapii nr 1, Centrum Urazowe Medycyny Ratunkowej i Katastrof, Szpital Uniwersytecki w Krakowie

Zakład Farmakologii Klinicznej Katedry Farmakologii, Wydział Lekarski, Uniwersytet Jagielloński Collegium Medicum, Kraków

Online publish date: 2020/04/21

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Neuropathic pain is a symptomatic diagnosis. The cause of neuropathic pain may be known and is usually an infection or injury. However, its cause is very often unknown in neuropathic pain. Neuropathic pain is characterised by altered reactivity of neurons at many levels of the nervous system – from peripheral nerve fibres to the cerebral cortex. The choice of individual drugs should result from both the clinical picture of the disease, the location and intensity of pain, comorbidities and other drugs used by the patient. A significant proportion of drugs used in the treatment of neuropathic pain is used off-label; hence, it is important to make the patient aware of the role of antiepileptic and antidepressant drugs in the treatment of neuropathic pain.

keywords:

Pregabalin and duloxetine in the treatment of neuropathic pain – why the use of off-label drugs is consistent with the standards of management and current medical knowledge

Jarosław Woroń 1, 2

neuropathic pain, pharmacotherapy, off-label use

Jarosław Woroń

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