Abstract
1/2011
vol. 6
Original paper
Programmed death of leukocytes through Fas and TNFR1 in malnourished patients with pancreatic cancer
Przegląd Gastroenterologiczny 2011; 6 (1): 30–35
Online publish date: 2011/03/01
Aim : To evaluate the status of programmed leukocyte death (apoptosis) in malnourished pancreatic cancer patients in comparison with healthy controls.
Material and methods : The percentage of leukocytes with death receptors Fas (CD95) and TNFR1 (CD120a) was investigated in 72 pancreatic cancer patients in comparison with 30 healthy volunteers. Percentages of cells with receptors were assessed by flow cytometry.
Results : Results of the study show a significantly higher percentage of CD95+/CD3– cells and lymphocytes with TNFR1 in the group with pancreatic cancer in comparison with healthy controls.
Conclusions : Our studies show up-regulation of the pro-apoptotic signalling system in the leukocytes of patients with pancreatic cancer and a switch to apoptosis. These alterations may lead to leukocyte dysfunction and immune system suppression.
Material and methods : The percentage of leukocytes with death receptors Fas (CD95) and TNFR1 (CD120a) was investigated in 72 pancreatic cancer patients in comparison with 30 healthy volunteers. Percentages of cells with receptors were assessed by flow cytometry.
Results : Results of the study show a significantly higher percentage of CD95+/CD3– cells and lymphocytes with TNFR1 in the group with pancreatic cancer in comparison with healthy controls.
Conclusions : Our studies show up-regulation of the pro-apoptotic signalling system in the leukocytes of patients with pancreatic cancer and a switch to apoptosis. These alterations may lead to leukocyte dysfunction and immune system suppression.
Keywords
pancreatic cancer, apoptosis, immune dysfunction
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