Recurrent infections and immunodeficiency in a patient
with Sanfilippo syndrome (MPS type 3)

Öner Özdemir; Kübra Tokmak

doi:10.5114/pja.2026.159580

eISSN: 2391-6052
ISSN: 2353-3854

Alergologia Polska - Polish Journal of Allergology

Bieżący numer Archiwum Artykuły zaakceptowane O czasopiśmie Suplementy Zeszyty specjalne Rada naukowa Bazy indeksacyjne Prenumerata Kontakt Zasady publikacji prac Opłaty publikacyjne Standardy etyczne i procedury

Panel Redakcyjny

Zgłaszanie i recenzowanie prac online

Wyszukiwanie

Zasady redakcyjne

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

Otwarty dostęp

1/2026
vol. 13

Poleć ten artykuł:

Wyślij znajomemu

Skopiuj link:

Udostępnij:

streszczenie artykułu:

Opis przypadku

Recurrent infections and immunodeficiency in a patient with Sanfilippo syndrome (MPS type 3)

Öner Özdemir

¹

,

Kübra Çevik Tokmak

¹

Division of Allergy and Immunology, Department of Pediatrics, Research and Training Hospital of Sakarya, Sakarya University Medical Faculty, Adapazarı, Sakarya, Türkiye

DOI: https://doi.org/10.5114/pja.2026.159580

Data publikacji online: 2026/02/27

Pełna treść artykułu Pobierz cytowanie

Metryki PlumX:

Sanfilippo syndrome (mucopolysaccharidosis type III, MPS III) is a rare lysosomal storage disorder characterized by progressive neurodegeneration, behavioral abnormalities, and multisystemic involvement, with autosomal recessive inheritance. Recent findings suggest that immune system disorders may play a role in the pathogenesis and clinical complications of the disease, in addition to the classic neurological presentation. In this case, total IgG and subclass deficiencies were detected in an 18-year-old female patient who was being monitored for frequent respiratory tract infections, and intravenous immunoglobulin (IVIG) treatment was initiated with a diagnosis of humoral immunodeficiency. A significant decrease in the incidence of post-treatment infections and hospital admissions has been observed. Immune system involvement in MPS patients may increase the risk of infection. Therefore, immunological evaluation and appropriate treatment approaches are critical for improving quality of life.

POLECAMY

KONFERENCJE

• Webinar Testowy

Recurrent infections and immunodeficiency in a patient with Sanfilippo syndrome (MPS type 3)

Öner Özdemir 1 , Kübra Çevik Tokmak 1

Öner Özdemir

¹

,

Kübra Çevik Tokmak

¹