eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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SCImago Journal & Country Rank
2/2021
vol. 46
 
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abstract:
Clinical immunology

Relationship between Gd-IgA1 and TNFR1 in IgA nephropathy and IgA vasculitis nephritis in children – multicenter study

Małgorzata Mizerska-Wasiak
1
,
Łukasz Gajewski
2
,
Karolina Cichoń-Kawa
1
,
Agata Siejko
1
,
Jadwiga Małdyk
3
,
Anna Spława-Neyman
4
,
Jacek Zachwieja
4
,
Agnieszka Firszt-Adamczyk
5
,
Roman Stankiewicz
5
,
Magdalena Drożyńska-Duklas
6
,
Aleksandra Żurowska
6
,
Beata Bieniaś
7
,
Przemysław Sikora
7
,
Agnieszka Pukajło-Marczyk
8
,
Danuta Zwolińska
8
,
Maria Szczepańska
9
,
Monika Pawlak-Bratkowska
10
,
Marcin Tkaczyk
10
,
Anna Stelmaszczyk-Emmel
11
,
Małgorzata Pańczyk-Tomaszewska
1

1.
Department of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland
2.
Student’s Scientific Group at the Department of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland
3.
Department of Pathology, Medical University of Warsaw, Warsaw, Poland
4.
Department of Pediatric Nephrology and Dialysis, Poznan University of Medical Sciences, Poznań, Poland
5.
Department of Pediatrics and Nephrology, Ludwik Rydygier Hospital, Toruń, Poland
6.
Department of Pediatrics, Nephrology and Hypertension, Medical University of Gdańsk, Gdańsk, Poland
7.
Department of Pediatric Nephrology, Medical University of Lublin, Lublin, Poland
8.
Department of Pediatric Nephrology, Wroclaw Medical University, Wrocław, Poland
9.
Department of Pediatrics, SMDZ in Zabrze, Silesian Medical University, Zabrze, Poland
10.
Department of Pediatrics, Immunology and Nephrology, Polish Mother’s Memorial Hospital Research Institute, Łódź, Poland
11.
Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Warsaw, Poland
Cent Eur J Immunol 2021; 46 (2): 199-209
Online publish date: 2021/08/07
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Introduction
To evaluate the relationship between serum Gd-IgA1 (sGd-IgA1) and serum and urine TNFR1 (sTNFR1, uTNFR1) levels as possible prognostic factors in IgA nephropathy (IgAN) and IgA vasculitis nephritis (IgAVN).

Material and methods
From 299 patients from the Polish Registry of Pediatric IgAN and IgAVN, 60 children (24 IgAN and 36 IgAVN) were included in the study. The control group consisted of 20 healthy children. Proteinuria, haematuria, serum creatinine as well as IgA and C3 levels were measured and glomerular filtration rate (GFR) was calculated at onset and at the end of the follow-up. Kidney biopsy findings were evaluated using the Oxford classification. Serum Gd-IgA1 and serum and urine TNFR1 levels were measured at the end of follow-up.

Results
Serum Gd-IgA1 level was significantly higher in IgAN and IgAVN patients in comparison to the control group. Urine TNFR1 was significantly higher in IgAN than in IgAVN and the control group. We did not observe any differences in sTNFR1 level between IgAN, IgAVN and control groups. We found a positive correlation between Gd-IgA1 and creatinine (r = 0.34), and negative between Gd-IgA1 and GFR (r = –0.35) at the end of follow-up. We observed a negative correlation between uTNFR1/creatinine log and albumin level and protein/creatinine ratio. We did not find any correlations between Gd-IgA1 and TNFR1.

Conclusions
The prognostic value of sGd-IgA1 in children with IgAN and IgAVN has been confirmed. TNFR1 is not associated with Gd-IgA1 and is not a useful prognostic marker in children with IgAN/IgAVN and normal kidney function.

keywords:

IgA nephropathy, TNFR1, Gd-IgA1, IgA vasculitis nephritis, Henoch-Schönlein nephritis

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