Abstract
1/2012
vol. 50
Review article
Amyloid and prions: some biochemical investigations of cerebral
amyloidosis in mice
Folia Neuropathol 2012; 50 (1): 13-19
Online publish date: 2012/03/30
Prion-like transmission of protein aggregates or amyloid in several neurodegenerative diseases, such as Parkinson’s disease, Huntington’s disease and Alzheimer’s disease, in addition to the transmissible spongiform encephalopathies (or prion diseases), has been proposed recently. This is a controversial idea and, in this paper, we consider what we mean by a “prion”, and by “amyloid”, and present some biochemical investigations of cerebral prion amyloidosis in mice.
Keywords
prion, amyloid, transmissible spongiform encephalopathy, mouse, strains, time-resolved fluoroimmunoassay, cerebral amyloidosis, Alzheimer’s disease, Huntington’s disease, Parkinson’s disease
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