eISSN: 1897-4317
ISSN: 1895-5770
Gastroenterology Review/Przegląd Gastroenterologiczny
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SCImago Journal & Country Rank
3/2013
vol. 8
 
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abstract:
Original paper

Secretory phospholipase A2 activity is linked to hypercholesterolemia and gender in non-alcoholic fatty liver disease individuals

Joanna Raszeja-Wyszomirska
,
Krzysztof Safranow
,
Agnieszka Szynkowska
,
Ewa Stachowska

Prz Gastroenterol 2013; 8 (3): 172–175
Online publish date: 2013/07/04
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Introduction: Non-alcoholic fatty liver disease (NAFLD) is associated with the metabolic syndrome, which is a constellation of insulin resistance, central obesity, dyslipidemia and inflammation. During the inflammatory process polyunsaturated fatty acids are converted into proinflammatory hydroperoxides by the action of lipoxygenases, e.g. secretory phospholipase A2 (sPLA2).

Aim: The role of sPLA2 during progression of inflammation in NAFLD is practically unknown; therefore the aim of the study was to investigate sPLA2 activity in NAFLD patients.

Material and methods: Ninety-two patients with NAFLD and 20 healthy individuals were enrolled in the study. sPLA2 activity in plasma was evaluated by the ELISA method.

Results: There were no differences between NAFLD and healthy individuals in sPLA2 activity but among NAFLD individuals high sPLA2 activity was linked to male gender and high concentration of plasma cholesterol (hypercholesterolemia). A trend for a correlation between 8-epi-PGF III concentration in plasma and sPLA2 activity was observed.

Conclusions: sPLA2 is one of the main factors associated with progression of inflammatory diseases including NAFLD. A positive correlation between total cholesterol in plasma and activity of sPLA2 in men may contribute to the pathogenesis of NAFLD as well as progression to steatohepatitis according to novel “one hit” theory.
keywords:

secretory phospholipase A2, isoprostane, 8-epi-PGF III, hydroxyoctadecadienoic acid

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