eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
3/2018
vol. 43
 
Share:
Share:
abstract:
Clinical immunology

Serum adiponectin as a predictor of laboratory response to anti-TNF-α therapy in rheumatoid arthritis

Dorota Sikorska
,
Rafał Rutkowski
,
Joanna Łuczak
,
Włodzimierz Samborski
,
Janusz Witowski

(Centr Eur J Immunol 2018; 43 (3): 289-294)
Online publish date: 2018/10/30
View full text Get citation
 
PlumX metrics:
Introduction
While adiponectin is typically viewed as an anti-inflammatory mediator, such an activity of adiponectin in rheumatoid arthritis (RA) is not so obvious. In the present study we examined whether serum levels of adiponectin reflect the clinical phenotype of RA patients and/or correlate with severity of the disease and the response to anti-TNF-α therapy.

Material and methods
Twenty-one female RA patients qualified to receive anti-TNF-α treatment were prospectively assessed before and after 12 weeks of therapy. Patients underwent full clinical and biochemical assessment. Disease activity was assessed by the Modified Disease Activity Scores (DAS28). Serum concentrations of adiponectin were measured with an immunoassay. The individuals were divided into two subgroups according to whether their baseline serum adiponectin was below or above the median value. The subgroups did not differ in basic demographic, anthropometric, and clinical parameters.

Results
Anti-TNF-α treatment resulted in a significant clinical (DAS28) improvement in patients from both subgroups, but no significant differences between basal and post-treatment serum adiponectin concentrations were observed. However, patients with higher baseline adiponectin experienced a significant and more pronounced improvement in laboratory parameters of inflammation (ESR, CRP, neutrophil count, neutrophil-to-lymphocyte ratio).

Conclusions
It is possible that adiponectin exerts systemic anti-inflammatory effects independently of the local activity of RA.

keywords:

rheumatoid arthritis, inflammation, adiponectin, adipocytokines, anti-TNF-α treatment

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.