Przegląd Gastroenterologiczny

Abstract

6/2010 vol. 5
Review paper

TNF superfamily - mechanisms of action, biologic funtions and therapeutic possibilities

Anna Lubecka-Macura
,
Maciej Kohut
Przegląd Gastroenterologiczny 2010; 5 (6): 303–309
DOI: https://doi.org/10.5114/pg.2010.18472
Online publish date: 2010/12/08
View full text
Confronting perimenopausal women’s knowledge of coronary heart disease with their health behaviours. Controversial role of hormone replacement therapy in the protection of coronary heart disease
We present a brief historical introduction of tumour necrosis factor (TNF). Molecular structure and cellular origins are introduced. The TNF superfamily with its multiple members and variety of functions is summarized. Receptor activity and biological effects of TNF are discussed. Particular attention is drawn to TNF’s influence on neoplasms and inflammatory bowel diseases. Finally, anti-TNF therapies (including biological and small-molecule therapies) are described.

Keywords

TNF, inflammatory bowel diseases

Share
without publication fees
Coverage in
Indexed in
pubmed
Integrated with
integrated with publons
plagiat pl
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications