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4/2017
vol. 12
 
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Artykuł oryginalny

The incidence of HLA-DQ2/DQ8 in Turkish children with celiac disease and a comparison of the geographical distribution of HLA-DQ

Ahmet Basturk, Reha Artan, Aygen Yilmaz

Data publikacji online: 2017/12/14
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Introduction: Celiac disease (CD) is an auto-immune enteropathy that occurs in genetically pre-disposed people as a result of the consumption of gluten-containing foods.

Aim: To identify the incidence of HLA-DQ2 and HLA-DQ8 observed in children with CD.

Material and methods: In this study, we focused on children ranging in age from 2 to 18 years and diagnosed with celiac disease. In our patients diagnosed with CD, in addition to tissue transglutaminase antibodies (anti-tTG), we also evaluated HLA-DQ2 B1 and HLA-DQ8 B1 alleles using the method of polymerase chain reaction (PCR)/sequence-specific oligonucleotide probes (Luminex®). The detection of 0201/0202 for HLA-DQ2 allele and 0302 for HLA-DQ8 allele was accepted as a positive result.

Results: The mean age of our patients with celiac disease was 7.42 ±3.18 years, and the female/male ratio was 1.5/1. Seventy-six percent of our patients were HLA-DQ2 and/or HLA-DQ8 positive, 67% were HLA-DQ2 positive, and 25% were HLA-DQ8 positive. Nevertheless, 24% of them were HLA-DQ2 and HLA-DQ8 negative. The incidence of HLA-DQ2 in the control group was 18.8% with a significant difference compared to the HLA-DQ2 incidence in the patient group (67%) (p < 0.05). Similarly the HLA-DQ8 incidence in the control group (5.7%) was significantly lower than the incidence in the patient group (25%) (p < 0.05).

Conclusions: The incidence of the patients diagnosed with CD, who are HLA-DQ2 and HLA-DQ8 negative, varies among different populations.
referencje:
Trancone R, Jabri B. Celiac disease and gluten sensitivity. J Intern Med 2011; 269: 582-90.
Khan AN, Gregorie CJ, Tomasi TB. Histone deacetylase inhibitors induce TAP, LMP, Tapasin genes and MHC class I antigen presentation by melanoma cells. Cancer Immunol Immunother 2008; 57: 647-54.
Complete sequence and gene map of a human major histocompatibility complex. The MHC sequencing consortium. Nature 1999; 401: 921-3.
Sanfilipo F, Vaughn WK, Spees EK, et al. Benefits of HLA A and HLA B matching of graft and patient out come after cadaveric donor renal transplantation. N Eng J Med 1984; 311: 358-64.
Mearin ML, Biemond I, Peña AS, et al. HLA-DR phenotypes in Spanish celiac children: their contribution to the understanding of the genetics of the disease. Gut 1983; 24: 532-7.
Karell K, Louka AS, Moodie SJ, et al. HLA types in celiac disease patients not carrying the DQA1_05-DQB1_02 (DQ2) heterodimer: results from the European Genetics Cluster on Celiac Disease. Hum Immunol 2003; 64: 469-77.
Book L, Hart A, Black J, et al. Prevalance and clinical characteristics of celiac disease in Down syndrome in a US study. Am J Med Genet 2001; 98: 70-4.
Husby S, Koletzko S, Korponay-Szabó IR, et al. ESPGHAN Working Group on Celiac Disease Diagnosis; ESPGHAN Gastroenterology Committee. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of celiac disease. J Pediatr Gastroenterol Nutr 2012; 54: 136-60.
Ensari A. Gluten sensitive enteropathy: controversies in diagnosis and classification. Arch Pathol Lab Med 2010; 134: 826-36.
Klitz W, Maiers M, Spellman S, et al. New HLA haplotype frequency reference standards: high-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans. Tissue Antigens 2003; 62: 296-307.
Etiz P. The distribution of HLA antigens in our region. Master’s thesis. Adana 2009.
Temiz N. Determination of types and frequencies HLA (human leukocyte antigens) in Mediterranean region. Master’s thesis. Kahramanmaraş 2005.
Vidales MC, Zubillaga P, Zubillaga I, Alfonso-Sánchez MA. Allele and haplotype frequencies for HLA class II (DQA1 and DQB1) loci in patients with celiac disease from Spain. Hum Immunol 2004; 65: 352-8.
Piccini B, Vascotto M, Serracca L, et al. HLA-DQ typing in the diagnostic algorithm of celiac disease. Rev Esp Enferm Dig 2012; 104: 248-54.
Pallav K, Kabbani T, Tariq S, et al. Clinical utility of celiac disease-associated HLA testing. Dig Dis Sci 2014; 59: 2199-206.
Delgado JF, Amengual MJ, Veraguas A, et al. Paediatric celiac patients carrying the HLA-DR7-DQ2 and HLA-DR3-DQ2 haplotypes display small clinical differences. Acta Paediatr 2014; 103: e238-42.
Kuloğlu Z, Doğanci T, Kansu A, et al. HLA types in Turkish children with celiac disease. Turk J Pediatr 2008; 50: 515-20.
Tümer L, Altuntaş B, Hasanoglu A, et al. Pattern of human leukocyte antigens in Turkish children with celiac disease. Pediatr Int 2000; 42: 678-81.
Djilali-Saiah I, Schmitz J, Harfouch-Hammoud E, et al. CTLA-4 gene polymorphism is associated with predisposition to celiac disease. Gut 1998; 43: 187-9.
Kaur G, Sarkar N, Bhatnagar S, et al. Pediatric celiac disease in India is associated with multiple DR3-DQ2 haplotypes. Hum Immunol 2002; 63: 677-82.
Erriu M, Abbate GM, Pili FM, et al. Oral signs and HLA-DQB1∗02 haplotypes in the celiac paediatric patient: a preliminary study. Autoimmune Dis 2013; 2013: 389590.
Zamani M, Modares-Sadegi M, Shirvani F, et al. The involvement of the HLA-DQB1 alleles in the risk and the severity of Iranian celiac disease patients. Int J Immunogenet 2014; 41: 312-7.
Koskinen L, Romanos J, Kaukinen K, et al. Cost-effective HLA typing with tagging SNPs predicts celiac disease risk haplotypes in the Finnish, Hungarian, and Italian populations.
Immunogenetics 2009; 61: 247-56.
Alarida K, Harown J, Di Pierro MR, et al. HLA-DQ2 and -DQ8 genotypes in celiac and healthy Libyan children. Dig Liver Dis 2010; 42: 425-7.
Catassi C, Yachha SK. The global village of celiac disease. In: Frontiers in Celiac Disease. Fasano A, Troncone R, Branski D (eds). Karger Basel, Switzerland 2008; 23-31.
Rostami-Nejad M, Romanos J, Rostami K, et al. Allele and haplotype frequencies for HLA-DQ in Iranian celiac disease patients. World J Gastroenterol 2014; 20: 6302-8.
Pérez-Bravo F, Araya M, Mondragón A, et al. Genetic differences in HLA-DQA1* and DQB1* allelic distributions between celiac and control children in Santiago, Chile. Hum Immunol 1999; 60: 262-7.
Sumník Z, Kolousková S, Cinek O, et al. HLA-DQA1*05-DQB1*0201 positivity predisposes to celiac disease in Czech diabetic children. Acta Paediatr 2000; 89: 1426-30.
Neuhausen SL, Weizman Z, Camp NJ, et al. HLA DQA1-DQB1 genotypes in Bedouin families with celiac disease. Hum Immunol 2002; 63: 502-7.
Johnson TC, Diamond B, Memeo L, et al. Relationship of HLA-DQ8 and severity of celiac disease: comparison of New York and Parisian cohorts. Clin Gastroenterol Hepatol 2004; 2: 888-94.
El-Akawi ZJ, Al-Hattab DM, Migdady MA. Frequency of HLA-DQA1*0501 and DQB1*0201 alleles in patients with celiac disease, their first-degree relatives and controls in Jordan. Ann Trop Paediatr 2010; 30: 305-9.
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