eISSN: 1897-4317
ISSN: 1895-5770
Gastroenterology Review/Przegląd Gastroenterologiczny
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SCImago Journal & Country Rank
4/2012
vol. 7
 
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abstract:
Review paper

The pathogenesis of chronic fatigue in primary biliary cirrhosis

Joanna Raszeja-Wyszomirska
,
Ewa Wunsch
,
Dorota Koziarska
,
Piotr Milkiewicz

Prz Gastroenterol 2012; 7 (4): 192–196
Online publish date: 2012/09/23
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Primary biliary cirrhosis (PBC) is a chronic cholestatic disease affecting middle-aged women. In addition to the potential for liver-related morbidity and mortality, it is recognized that patients with PBC frequently suffer from a marked impairment in their quality of life. In various studies fatigue has been identified as one of the principal factors contributing to this functional impairment in patients with PBC. It is also considered as a negative prognostic factor. In this article we discuss the pathogenesis and clinical issues related to chronic fatigue in PBC.
keywords:

primary biliary cirrhosis, fatigue, autonomic dysfunction

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