Abstract
4/2007
vol. 45
Alpha-synuclein decreases arachidonic acid incorporation into rat striatal synaptoneurosomes
Folia Neuropathol 2007; 45 (4): 230-235
Online publish date: 2007/12/21
In the present study we investigated the role of alpha-synuclein (ASN) and its fragment NAC in arachidonic acid (AA) turnover in the rat brain. Our data indicated that ASN (10 µM) inhibited [3H]AA incorporation into phosphatidylethanolamine (PE), phosphatidylcholine (PC) and phosphatidylserine (PS) together with phosphatidic acid (PA) by 13%, 27% and 38%, respectively. NAC (10 µM) reduced [3H]AA incorporation into PC and PA + PS by 17% and 34%, respectively. Because ASN and NAC lower the level of AA-CoA we suggest that inhibition of AA-CoA synthase is responsible for disturbed [3H]AA incorporation. In conclusion, ASN and NAC modulate phospholipid compositions in plasma membranes and affect synaptic endings function.
Keywords
striatum, alpha-synuclein, non-amyloid beta component of Alzheimer’s disease amyloid, arachidonic acid
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