eISSN: 1897-4317
ISSN: 1895-5770
Gastroenterology Review/Przegląd Gastroenterologiczny
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SCImago Journal & Country Rank
3/2010
vol. 5
 
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abstract:
Review paper

Butyric acid in gastrointestinal tract

Anna Kotunia
,
Piotr Pietrzak
,
Paul Guilloteau
,
Romuald Zabielski

Przegląd Gastroenterologiczny 2010; 5 (3): 117–122
Online publish date: 2010/06/24
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Sodium butyrate (NaB) dissociating to butyric acid is regarded as a molecule which may be potentially applied in gastrointestinal mucosa treatment. In humans, NaB is produced by colonic bacteria. In certain cases, NaB production may be diminished; hence supplementation with exogenous NaB is essential the more so as NaB is a major energy source for colonocytes. In this review, we would like to discuss present knowledge about the role of NaB in the gastrointestinal tract, in particular its trophic, proapoptotic, cytoprotective and anti-inflammatory role.
keywords:

sodium butyrate, development, cytoprotection, apoptosis

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