Does lipopolysaccharide-based neuroinflammation induce microglia polarization?

Daniel Hernandez Baltazar; Rasajna Nadella; Abril Barrientos Bonilla; Yazmin Flores Martínez; Abraham Olguín; Paola Heman Bozadas; María Rovirosa Hernández; Iliana Cibrián Llanderal

doi:10.5114/fn.2020.96755

Abstract

2/2020 vol. 58

Review paper

Does lipopolysaccharide-based neuroinflammation induce microglia polarization?

Daniel Hernandez Baltazar ¹

,

Rasajna Nadella ²

,

Abril Alondra Barrientos Bonilla ³

,

Yazmin Montserrat Flores Martínez ⁴

,

Abraham Puga Olguín ⁵

,

Paola Heman Bozadas ⁶

,

María de Jesús Rovirosa Hernández ⁶

,

Iliana Tamara Cibrián Llanderal ⁶

CONACyT-Instituto de Neuroetología, Universidad Veracruzana, Xalapa, Veracruz, Mexico
IIIT Srikakulam, Rajiv Gandhi University of Knowledge Technologies (RGUKT), India
Centro de Investigaciones Biomédicas, Universidad Veracruzana, Xalapa, Veracruz, Mexico
Programa Institucional de Biomedicina Molecular, Escuela Nacional de Medicina y Homeopatía, Instituto Politécnico Nacional, Ciudad de México, Mexico
Instituto Interdisciplinario de Investigaciones de la Universidad de Xalapa, Xalapa, Veracruz, Mexico
Instituto de Neuroetología, Universidad Veracruzana, Xalapa, Veracruz, Mexico

Folia Neuropathol 2020; 58 (2): 113-122

DOI: https://doi.org/10.5114/fn.2020.96755

Online publish date: 2020/06/30

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AMA

Hernandez Baltazar D, Nadella R, Barrientos Bonilla AA, et al. Does lipopolysaccharide-based neuroinflammation induce microglia polarization?. Folia Neuropathologica. 2020;58(2):113-122. doi:10.5114/fn.2020.96755.

APA

Hernandez Baltazar, D., Nadella, R., Barrientos Bonilla, A. A., Flores Martínez, Y. M., Olguín, A. P., & Heman Bozadas, P. et al. (2020). Does lipopolysaccharide-based neuroinflammation induce microglia polarization?. Folia Neuropathologica, 58(2), 113-122. https://doi.org/10.5114/fn.2020.96755

Chicago

Hernandez Baltazar, Daniel, Rasajna Nadella, Abril A Barrientos Bonilla, Yazmin M Flores Martínez, Abraham P Olguín, Paola Heman Bozadas, and María D Rovirosa Hernández et al. 2020. "Does lipopolysaccharide-based neuroinflammation induce microglia polarization?". Folia Neuropathologica 58 (2): 113-122. doi:10.5114/fn.2020.96755.

Harvard

Hernandez Baltazar, D., Nadella, R., Barrientos Bonilla, A., Flores Martínez, Y., Olguín, A., Heman Bozadas, P., Rovirosa Hernández, M., and Cibrián Llanderal, I. (2020). Does lipopolysaccharide-based neuroinflammation induce microglia polarization?. Folia Neuropathologica, 58(2), pp.113-122. https://doi.org/10.5114/fn.2020.96755

MLA

Hernandez Baltazar, Daniel et al. "Does lipopolysaccharide-based neuroinflammation induce microglia polarization?." Folia Neuropathologica, vol. 58, no. 2, 2020, pp. 113-122. doi:10.5114/fn.2020.96755.

Vancouver

Hernandez Baltazar D, Nadella R, Barrientos Bonilla A, Flores Martínez Y, Olguín A, Heman Bozadas P et al. Does lipopolysaccharide-based neuroinflammation induce microglia polarization?. Folia Neuropathologica. 2020;58(2):113-122. doi:10.5114/fn.2020.96755.

Lipopolysaccharide (LPS) is a potent immunogen when administered locally and/or systemically. The peripheral immunization with LPS could contribute to the progression of neurological diseases because a strong link between neuroinflammation and dopaminergic degeneration has been found. The switch between the survival and neuronal death in substantia nigra could be related to M1 (neurotoxic) and M2 (neuroprotective) microglia phenotypes. In this review, we present the current findings about microglia roles, biomarkers, and natural or synthetic immune modulators determined in the LPS-based murine model.

Keywords

cell signalling, lipopolysaccharide, proliferation, microglia cells, neuroinflammation

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