Abstract
3/2021
vol. 59
Original paper
Identification of miR-21-5p/TET1-negative regulation pair in the aggressiveness of glioma cells
- Neurology Department, Liaocheng Second People’s Hospital, Liaocheng, Shandong, China
- The Second People’s Hospital of Shenxian County, Shenxian, Shandong, China
- Department of Neurology, Ward 2, Linqing People’s Hospital, Linqing, Shandong, China
- Department of Neurology, Ward 4, People’s Hospital of Pingyi County, Pingyi, Shandong, China
Folia Neuropathol 2021; 59 (3): 239-248
Online publish date: 2021/10/05
Increasing evidence highlights that microRNAs (miRNAs) drive glioma initiation and development. Nevertheless, the underlying role of miR-21-5p in glioma is elusive. Hence, we evaluated the underlying role of miR-21-5p in glioma progression. Microarray data analysis provided data indicating that the miR-21-5p level was elevated in glioma. Silenced miR-21-5p suppressed glioma cell growth and invasion. Additionally, our results disclosed that ten-eleven translocation 1 (TET1) was directly targeted by miR-21-5p. Furthermore, antagomir-21-5p restrained glioma cell growth in a xenograft tumour model. In rescue experiments, knockdown of TET1 neutralized miR-21-5p silence-mediated inhibitory function on glioma cell aggressiveness. Taken together, miR-21-5p exerted its carcinogenic effect in glioma cell growth and invasin by targeting TET1.
Keywords
glioma, proliferation, invasion, MiR-21-5p, TET1
Integrated with
