eISSN: 1509-572x
ISSN: 1641-4640
Folia Neuropathologica
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2/2021
vol. 59
 
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abstract:
Original paper

MiR-125a-5p silencing inhibits cerebral ischemia-induced injury through targeting IGFBP3

Bo Song
1
,
Jing Xu
1
,
Ping Zhong
1
,
Lei Fang
1

1.
Department of Neurology, Qingdao Central Hospital, Qingdao, Shandong, China
Folia Neuropathol 2021; 59 (2): 121-130
Online publish date: 2021/06/30
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Dysregulated microRNAs (miRNAs) are crucial regulators of cerebrovascular conditions, including ischemic stroke. Circulating miR-125a-5p is associated with ischemic stroke and may have clinical utility as an early diagnostic biomarker. This study conducted a series of experiments that were designed to elucidate the regulatory action of miR-125a-5p in ischemic brain injury and its underlying mechanisms. The results of this study found that the expression of miR-125a-5p was increased in BV2 microglial cells under oxygen-glucose deprivation/reoxygenation (OGD/R) setting, as well as in rat brain tissue after middle cerebral artery occlusion (MCAO). OGD/R triggered BV2 microglial cell apoptosis, whereas downregulation of miRNA-125a-5p suppressed the apoptosis rate in OGD/R-induced BV2 microglial cells. Subsequently, insulin-like growth factor binding protein 3 (IGFBP3) is a molecular target of miR-125a-5p, and IGFBP3 knockdown reversed the effects of miR-125a-5p inhibitor on BV2 microglial cells in vitro. These data supported the fact that miR-125a-5p silencing protects against cerebral ischemia-induced injury by targeting IGFBP3.
keywords:

miR-125a-5p, IGFBP3, apoptosis, ischemic stroke


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