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Gastroenterology Review/Przegląd Gastroenterologiczny
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Artykuł oryginalny

The efficacy and duration of treatment with propranolol in children with cyclic vomiting syndrome in southern Iran

Mahmoud Haghighat, Hajar Memari, Naser Honar, Seyed Mohsen Dehghani, Mohammad-Hadi Imanieh, Seyed-Javad Injoo, Hazhir Javaherizadeh

Data publikacji online: 2017/12/14
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Introduction: Cyclic vomiting syndrome is a functional disorder characterised by repeated episodes of nausea and vomiting with symptom-free intervals between the attacks. Cyclic vomiting syndrome is a migraine equivalent; therefore, anti-migraine medications are effective for cyclic vomiting syndrome prophylaxis, but duration of treatment is not clear.

Aim: To determine the efficacy and duration of drug therapy in cyclic vomiting syndrome.

Material and methods: This study was conducted on 206 cases of cyclic vomiting syndrome, who were treated with propranolol as prophylaxis. After they were symptom-free for at least 9 months, propranolol was tapered and discontinued and then they were followed for at least 6 months after drug withdrawal for evaluation of recurrence.

Results: The study subjects included 127 boys and 79 girls. The mean age of symptom onset was 3.4 years (range: 3 months to 14.5 years) and the mean age at the time of diagnosis was 5.7 years (range: 8.4 months to 18 years). Among the 206 patients in whom propranolol was discontinued, only 16 (7.8%) subjects developed recurrence of symptoms in the 6-month follow-up period.

Conclusions: There is no need to continue prophylaxis of cyclic vomiting syndrome for a long time. It is also possible to make the duration of drug therapy shorter, which is useful for the convenience of the patients and prevention of drug side effects.
Lee LY, Abbott L, Moodie S, et al. Cyclic vomiting syndrome in 28 patients: demographics, features and outcomes. Eur J Gastroenterol Hepatol 2012; 24: 939-43.
Sunku B. Cyclic vomiting syndrome: a disorder of all ages. Gastroenterol Hepatol 2009; 5: 507-15.
Lin YP, Ni YH, Weng WC, et al. Cyclic vomiting syndrome and migraine in children. J Formos Med Assoc 2011; 110: 382-7.
Hejazi RA, McCallum RW. Cyclic vomiting syndrome in adults: rediscovering and redefining an old entity. Aliment Pharmacol Ther 2011; 34: 263-73.
Shin YK, Kwon JG, Kim KY, et al. A case of cyclic vomiting syndrome responding to gonadotropin-releasing hormone analogue. J Neurogastroenterol Motil 2010; 16: 77-82.
Pareek N, Fleisher DR, Abell T. Cyclic vomiting syndrome: what a gastroenterologist needs to know. Am J Gastroenterol 2007; 102: 2832-40.
Erturk O, Uluduz D, Karaali-Savrun F. Efficacy of nebivolol and amitriptyline in the prophylaxis of cyclic vomiting syndrome: a case report. Neurologist 2010; 16: 313-4.
Hejazi RA, Reddymasu SC, Namin F, et al. Efficacy of tricyclic antidepressant therapy in adults with cyclic vomiting syndrome: a two-year follow-up study. J Clin Gastroenterol 2010; 44: 18-21.
Forbes D, Fairbrother S. Cyclic nausea and vomiting in childhood. Aust Fam Physician 2008; 37: 33-6.
Olmez A, Kose G, Turanli G. Cyclic vomiting with generalized epileptiform discharges responsive to topiramate therapy. Pediatr Neurol 2006; 35: 348-51.
Yang HR. Recent concepts on cyclic vomiting syndrome in children. J Neurogastroenterol Motil 2010; 16: 139-47.
Li BU, Lefevre F, Chelimsky GG, et al. North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition consensus statement on the diagnosis and management of cyclic vomiting syndrome. J Pediatr Gastroenterol Nutr 2008; 47: 379-93.
Chow S, Goldman RD. Treating children’s cyclic vomiting. Can Fam Physician 2007; 53: 417-9.
Sudel B, Li BU. Treatment options for cyclic vomiting syndrome. Curr Treat Options Gastroenterol 2005; 8: 387-95.
Paul SP, Barnard P, Soondrum K, et al. Antimigraine (low-amine) diet may be helpful in children with cyclic vomiting syndrome. J Pediatr Gastroenterol Nutr 2012; 54: 698-9.
Abraham MB, Porter P. Clonidine in cyclic vomiting. J Pediatr Gastroenterol Nutr 2011; 53: 219-21.
Haan J, Kors EE, Ferrari MD. Familial cyclic vomiting syndrome. Cephalalgia 2002; 22: 552-54.
Hikita T, Kodama H, Kaneko S, et al. Sumatriptan as a treatment for cyclic vomiting syndrome: a clinical trial. Cephalalgia 2011; 31: 504-7.
Lee LY, Abbott L, Mahlangu B, et al. The management of cyclic vomiting syndrome: a systematic review. Eur J Gastroenterol Hepatol 2012; 24: 1001-6.
Li BU, Misiewicz L. Cyclic vomiting syndrome: a brain-gut disorder. Gastroenterol Clin North Am 2003; 32: 997-1019.
Li BU, Balint JP. Cyclic vomiting syndrome: evolution in our understanding of a brain-gut disorder. Adv Pediatr 2000; 47: 117-60.
Haghighat M, Rafie SM, Dehghani SM, et al. Cyclic vomiting syndrome in children: experience with 181 cases from southern Iran. World J Gastroenterol 2007; 13: 1833-6.
Boles RG, Lovett-Barr MR, Preston A, et al. Treatment of cyclic vomiting syndrome with co-enzyme Q10 and amitriptyline, a retrospective study. BMC Neurol 2010; 10: 10.
Hejazi RA, Lavenbarg TH, Foran P, et al. Who are the nonresponders to standard treatment with tricyclic antidepressant agents for cyclic vomiting syndrome in adults? Aliment Pharmacol Ther 2010; 31: 295-301.
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