Folia Neuropathologica
eISSN: 1509-572x
ISSN: 1641-4640
Folia Neuropathologica
Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Search
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications
Share:
Send email
Share:
abstract:
Review paper

The role of synaptic plasticity in Alzheimer’s disease: from molecular mechanisms to therapeutic targets

Yunyun Li
1
,
Sichong Li
1
,
Jing Ma
1
,
Jing Zhao
2
,
Ning Ning
1
,
Jianfang Sun
2

  1. Department of Neurology, The 942nd Hospital of PLA Joint Logistics Support Force, Yinchuan, Ningxia Hui Autonomous Region 750001, China
  2. Cadre Ward, The 942nd Hospital of PLA Joint Logistics Support Force, Yinchuan, Ningxia Hui Autonomous Region 750001, China
Folia Neuropathol 2025; 63
DOI: https://doi.org/10.5114/fn.2025.156508
Online publish date: 2025/12/21
View full text Get citation
 
PlumX metrics:
Alzheimer’s disease (AD) is characterized by a complex pathophysiology, involving abnormal aggregation of amyloid b (Ab) and tau proteins, neuroinflammatory responses, and significant synaptic dysfunction, which collectively contribute to cognitive decline. This review offers a novel perspective by focusing on the pivotal role of synaptic plasticity in the pathogenesis of AD, underscoring its potential as a therapeutic target. The study uniquely synthesizes current molecular and clinical research to illustrate how Ab and tau pathologies disrupt synaptic signaling and structure, further exacerbated by neuroinflammation. We explore both pharmacological interventions, such as BACE1 inhibitors and tau stabilizers, and non-pharmacological strategies, including cognitive therapy and neuromodulation techniques, which have shown promise in modulating synaptic plasticity and slowing cognitive deterioration. Despite these advancements, the field faces significant challenges, including the complexity of AD’s underlying mechanisms and limitations in early diagnosis. This review not only highlights the significance of synaptic plasticity in AD but also proposes future research directions that could lead to innovative therapeutic approaches, offering new hope for effective treatment strategies.
keywords:

synaptic plasticity, Alzheimer’s disease, amyloid b, neuroinflammation, neurotransmitter release, tau protein, therapeutic interventions, cognitive decline

  
Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2025 Termedia Sp. z o.o.
Developed by Bentus.