eISSN: 1689-3530
ISSN: 0867-4361
Alcoholism and Drug Addiction/Alkoholizm i Narkomania
Bieżący numer Archiwum Online first O czasopiśmie Rada naukowa Bazy indeksacyjne Prenumerata Kontakt Zasady publikacji prac Standardy etyczne i procedury
4/2021
vol. 34
 
Poleć ten artykuł:
Udostępnij:
więcej
 
 
Artykuł oryginalny

Stan wiedzy Polaków na temat nowotworów związanych z alkoholem

Michał Bujalski
1

1.
Institute of Psychiatry and Neurology, Department of Studies on Alcoholism and Drug Dependence, Warsaw, Poland
Alcohol Drug Addict 2021; 34 (4): 247-256
Data publikacji online: 2021/12/29
Plik artykułu:
- AIN-Bujalski.pdf  [0.41 MB]
Pobierz cytowanie
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
 

INTRODUCTION

More than 30 years ago alcohol was classified as a carcinogen by the International Agency for Research on Cancer and the World Health Organization [1]. There is strong evidence to support a causal association between alcohol and cancer of the mouth, throat, oesophagus, breast, liver and colon [2]. The risk of alcohol-attributable cancer is currently growing [3, 4] as, in 2016, there were about 80 000 alcohol-attributable cancer deaths in the EU [5]. The recent data shows that in the WHO European Region, the most common cancer due to alcohol consumption is breast cancer in women and colorectum cancer in men [6].
Alcohol causes cancer in multiple ways, including impairing DNA repair, dysregulation of sex hormones and increasing absorption of carcinogens from tobacco [7]. For alcohol-attributable cancer, there is a dose-response relationship meaning the higher the alcohol consumption, the higher the risk of cancer incidence [5]. Several metanalyses show that alcohol consumption is a significant risk factor for upper and lower digestive tract cancer. In a study by Pelucchi et al. [8], heavy alcohol consumption was significantly associated with a 5-fold increase in the risk of oral and pharyngeal cancer and oesophageal squamous cell carcinoma, a 2.5-fold increase for laryngeal cancer, a 50% increase for colorectal and breast cancer and 30% for pancreatic cancer. Authors stressed that at low doses of alcohol consumption (less than 1 drink per day) the risk for oral and pharyngeal cancer also increased by about 20% and 30% for oesophageal carcinoma. Other metanalyses confirmed that even light and moderate drinking increases the risk of oral cavity, pharynx, oesophagus and breast cancer as carcinogenesis can be enhanced with relatively low daily doses of ethanol [9-11]. A systematic review of 15 meta-analyses proved the existence of a dose–response relationship between alcohol consumption and the risk of breast cancer even at low levels of consumption. Women who were light alcohol consumers made up 19% of alcohol-attributable breast cancer cases and 17.5% of breast cancer related deaths [11].
The evidence on alcohol–cancer link derives also from cohort and modelling studies. In a cohort study by Schütze et al. [12] 10% and 3% of the incidence of total cancer was attributable to alcohol consumption (former and current) among men and women respectively, whereas for selected cancer the figures were much higher at 44% and 25% for upper aerodigestive tract, 33% and 18% for liver and 17% and 4% for colorectal cancer for men and women respectively. The recent modelling study published in Lancet Oncology shows that 4.1% (more than 740 000 cases) of all new cancer cases globally in 2020 were attributable to alcohol use. The authors noted that the highest risk of alcohol-attributable cancer occurs in Eastern Asia (5.7%) and Eastern Europe (5.6%). Although the largest burden of alcohol-attributable cancer was represented by heavy alcohol use (47%), the incidence of cancer among moderate drinkers reached 14% [13]. While the proportion of specific alcohol-attributable cancer may not seem large at a first glance even a small increase can be of great importance considering the high prevalence of this kind of cancer in the population [9].
Although the link between alcohol and cancer has been established on the vast amount of scientific evidence, there is still a gap in research on the public awareness of alcohol-attributable cancer. In a French study, 60% respondents acknowledged the existence of a link between alcohol use and cancer. However, beliefs denying cancer risk from drinking were frequent among men, older respondents and those with low incomes [14]. Studies among Australian drinkers found that cancer was the least recognised detrimental effect of alcohol consumption [15, 16]. The same was confirmed in the studies from US, Canada and EU, leading to the conclusion that the risk from alcohol–cancer link might be not fully understood by the general public [17]. Research also shows that although people can be aware of carcinogenic effects of alcohol use, they have several misconceptions about the risks associated with alcohol drinking, including the most common belief about the beneficial effects of wine consumption [18]. Some of these misconceptions can be attributed to the activities of alcohol producers who downplay or deny the existence of an association between alcohol drinking and cancer [19].
The gap in knowledge on public perception of cancer risk associated with alcohol use is also a problem in Poland where cancer incidence, despite some recent improvements, is still relatively high [20] Therefore the objective of the present study was to examine sociodemographic and alcohol use variables in relation to alcohol cancer risk awareness in the Polish adult population. We sought to investigate the perception of the alcohol–cancer link and examine the impact of sociodemographic variables in order to improve cancer prevention and inform public health professionals and decision makers.

MATERIAL AND METHODS

Study design and research sample

A questionnaire examining alcohol origin cancer risk perception was administered through face-to-face interviews (N = 2000). We gathered a nationally representative sample of households in a two-stage sampling process. In the first stage, proportional stratified sampling was prepared on the basis of the national register of the territorial division of the country. The stratification was made in relation to the size of the population in voivodships and municipality size. During the second stage, random sampling with replacement was used for sampling municipalities, accounting for probabilities proportional to the number of municipality inhabitants. In the sampled households, the last birthday method was used to select the respondent among household residents between 18 and 64 years of age. Among them, 50.1% were women and 25% had a university degree. The majority of the survey respondents (87%) reported alcohol drinking in the past 12 months. The study was conducted between August and September 2019 with an overall response rate of 58%. The sample sociodemographic characteristics are presented in detail in Table I. The Research Ethics Board of Institute of Psychiatry and Neurology approved the study protocol.

Measures

Perceived cancer risk awareness was assessed by the question Which of the health disorders below do you think can be caused by alcohol use? Respondents selected from a list of nine items covering the following health problems: stroke, breast cancer, larynx cancer, oesophagus cancer, colon cancer, dependence, poisoning, liver cirrhosis and injuries. The responses to this question included: yes, no, and don’t know. For purposes of the current analysis, only the issue of alcohol-attributable cancer is investigated.
Data on age, gender, education and monthly household income were obtained from respondents during interviews. Monthly household income per capita was calculated by summing up the monthly net income of all members of household and then divided by the number of household members. Moreover, each respondent was asked to provide information on alcohol consumption. The volume of alcohol consumption was assessed using beverage-specific quantity-frequency (BSQF) and risky single occasion drinking (RSOD) method. This method is based on the aggregation of average consumption of three alcoholic beverage types (spirits, wine, beer) combined with risky drinking occasions during past 12 months (drinking more than 60 grams of ethanol in a single occasion for men and more than 40 grams for women). Reported annual volume of consumed alcohol (BSQF) was corrected for larger quantities consumed on single occasions (RSOD), which allowed us to estimate total alcohol consumption effectively [21]. After calculating the volume of pure alcohol consumed during past 12 months, respondents were divided into four groups according to number of alcohol units (10 grams of ethanol per unit) consumed per week: abstainers (no alcohol during past 12 months), moderate drinkers (up to 14 units of alcohol per week), risky drinkers (15-35 units of alcohol per week for women and 15-50 units for men) and harmful drinkers (more than 35 units of alcohol per week for women and more than 50 units for men). The data set was weighted based on the Statistics Poland data on voivodships, age and gender totals.

Analysis

We performed four separate multiple logistic regression models to explore the impact of sociodemographic variables and alcohol use on the awareness of four specific alcohol-attributable cancer. Each of the investigated cancer (breast, larynx, oesophagus, colon) was regressed against drinker category, gender, age group, level of education and household income per capita. The awareness of alcohol-induced cancer was the outcome variable recoded to binary numbers (yes = 1; other = 0). For logistic regression analyses, we reported odds ratios (ORs) and their 95% confidence interval (95% CI). All correlation coefficients were below 0.3.

RESULTS

Overall, 67% of respondents indicated at least one of the four alcohol-attributable cancer types. The highest percentage of respondents indicated cancer of the colon (57%), oesophagus (52%) and larynx (44%). However, only a minority found breast cancer to be alcohol attributable (15%). As Table II shows, abstainers, moderate drinkers and risky drinkers more often indicated alcohol-attributable cancer awareness than harmful drinkers. Women more often than men reported awareness with exception of breast cancer. Older respondents were more aware of larynx cancer and less aware of breast cancer while the awareness of oesophagus and colon cancer were similar across age categories.
The education level did not greatly differentiate the awareness with exception of colon cancer. The awareness of breast cancer increased with monthly household per capita income. The awareness of larynx and oesophagus cancer was the same or almost the same among the lowest and highest household incomes. Those with the lowest household incomes were also least aware of colon cancer. The differences in indication of any cancer were less pronounced in most of analysed variables comparing to specific cancer categories. Table II also provides population estimates of alcohol-attributable cancer awareness in Poland.
Table III reports the odd ratios for binary logistic regression in which we investigated four types of alcohol-attributable cancer. Data shows that an increase in total alcohol consumption (as it determines the drinker category) was predictive for larynx cancer awareness. However, on the basis of our data, we cannot conclude there is a dose-response relationship. It seems that harmful drinkers are generally less aware of alcohol-attributable cancer risk. Some exceptions to this rule were found between risky and harmful drinkers in case of oesophagus cancer and between abstainers and harmful drinkers in case of colon cancer awareness. From the set of sociodemographic variables, only gender and to some extent age were correlated with increased awareness of some of alcohol cancer while income category was correlated negatively. No statistically significant effects on cancer awareness were found for education level. Women were more likely than men to report oesophagus and colon cancer awareness. Respondents’ age in general did not affect the outcome variable with exception of the youngest age group (18-29) more likely to report breast cancer awareness. Respondents from the two lowest household income categories were less likely to report concerns about the link between alcohol use and breast cancer. Similarly, those from the lowest income category were also less likely to acknowledge the link between alcohol use and colon cancer. Regarding the awareness of any cancer, the odds significantly increased among moderate and risky users, women and the youngest respondents. Overall, the analysed models explained only small amount of the variance (Nagelkerke R2 ranging from 0.016 to 0.024).

DISCUSSION

The present study provides an insight into the awareness of alcohol-attributable cancer in Poland. The results may contribute to the literature on alcohol risk perception and improve alcohol prevention and public health measures in the face of the growing burden of alcohol-related harm in Poland [22, 23]. Our findings suggest that the degree of alcohol contribution to cancer is clearly underestimated especially regarding breast cancer.
The results confirm the study findings in other countries that show considerable differences in cancer awareness observed between different types of cancer, including limited awareness of the link between alcohol and breast cancer [24, 25]. Although we found some sociodemographic differences in alcohol-attributable cancer awareness, education and age (with the exception of breast cancer) did not affect the outcome variables in tested regression models.
Harmful drinkers were less likely to be aware of the link between alcohol consumption and larynx, oesophagus and colon cancer. Although abstainers, moderate drinkers and even risky drinkers seem to be more concerned about the presented cancer issues, in the case of colon (and any cancer category) there was no differences between abstainers and harmful drinkers. This is to some extent consistent with the data on alcohol risk perception showing that increased alcohol use is commonly associated with risk denial, with the exception of abstainers having similar risk judgements as harmful drinkers [16, 21].
Women tend to be more aware of alcohol-attributable cancer in case of oesophagus and colon cancer which is consistent with results of the studies on alcohol risk perception and risk perception in general, showing that women are generally more concerned about health risks than men [16, 21, 26-28]. Interestingly, no gender differences were noted for breast cancer, which highlights the need to make the link between breast cancer and alcohol use more salient. The above findings concerning gender differences are in line with studies showing unrealistic perceptions of women’s personal breast cancer risk linked to beliefs, cultural norms and socioeconomic factors [29-31]. What is noteworthy is that the awareness of breast cancer decreased with the household income per capita as individuals from the two lowest income categories were about 40% less likely to identify the link between drinking and breast cancer than those with the highest incomes. The question remains why a similar effect was noted for people from the lowest household income category in the case of colon cancer while none was found in case of larynx and oesophagus cancer awareness.
The findings reported above suggest that there is a more common belief in the Polish adult population that alcohol may potentially affect the digestive track compared to other parts of the human body, for example the breasts in women. This belief prevails among those of lower socioeconomic position while the awareness of breast cancer is rarely reported by older people. Several possible explanations for this result are possible. First, the issue of alcohol-attributable breast cancer, along with other types of cancer, is absent from public debate and alcohol discourse. Therefore the general public lacks the knowledge on this specific risk. Second, our results suggest that health-consciousness can be found rather among individuals of higher socioeconomic position, which may translate into their higher awareness of alcohol-attributable cancer. Third, younger people are more familiar with the gender-related issues that may prompt specific female health problems. Surprisingly, the odds of alcohol-attributable cancer risk awareness were not affected by education, which reflects the relatively even knowledge gap across education levels. This finding however needs further in-depth inquiry on sociocultural determinants of perceived alcohol risks.
Health risks receiving small media coverage are less important to the general public so awareness of alcohol-attributable cancer can be increased through public and media campaigns [32, 33]. Efforts of this kind are particularly needed in the case of breast cancer and should target all drinkers regardless of gender, age and education in Poland. Future research could focus on more in-depth analyses of the alcohol–cancer link. More than four types of alcohol-attributable cancer ought to be investigated both prompted and unprompted responses on cancer risk compared to deliver more conservative estimations of cancer awareness. Finally, to provide further evidence on how people perceive cancer risk, research should employ both quantitative and qualitative approaches to explore complex issue of alcohol risk perception.

Study limitations

First, we used prompted responses in the question on alcohol-attributable cancer types. Prompted awareness in surveys is generally higher than awareness measured by an open-ended question (unprompted awareness) as during interviews individuals may associate cancer responses with detrimental effects of drinking without fully understanding the link between alcohol consumption and cancer [24, 34]. This most probably resulted in a higher number of positive responses in our study. As we already emphasised above, the prevalence of awareness of the alcohol–cancer link in Poland should be therefore confirmed in future studies testing both prompted and unprompted responses. Moreover, awareness of cancer origin differs between various cancer types [24, 25], which could affect the outcomes in the context of alcohol consumption being most commonly associated with the aerodigestive track cancer. Second, our study may deliver a limited picture of cancer awareness as the survey covered only the working population (aged 18-64). When surveying older individuals, the results would surely differ as knowledge of cancer morbidity and mortality is generally higher in older than younger cohorts. Third, this study also has shortcomings resulting from a moderate response rate (58%) and therefore might include some response bias.

CONCLUSIONS

The results of current study emphasise the vital need to include the evidence on alcohol-attributable cancer in alcohol public awareness campaigns, with particular attention to breast cancer and the growing alcohol consumption among women. Apart of public risk messages, communication on alcohol-attributable cancer from medical professionals is essential and can be implemented in out-patient settings and during brief interventions. Moreover, the strong scientific evidence on the dose-response relationship between alcohol and various types of cancer shows the urgent need to strengthen alcohol-control policy measures.

Conflict of interest/Konflikt interesów

None declared./Nie występuje.

Financial support/Finansowanie

Research was financed by the State Agency for the Prevention of Alcohol-Related Problems from the National Health Programme resources for 2016-2020, agreement no 91/40/3.4.3/19/DEA. Badanie było finansowane przez Państwową Agencję Rozwiązywania Problemów Alko- holowych ze środków Narodowego Programu Zdrowia na lata 2016-2020, nr umowy 91/40/3.4.3/19/DEA.

Ethics/Etyka

The work described in this article has been carried out in accordance with the Code of Ethics of the World Medical Association (Declaration of Helsinki) on medical research involving human subjects, Uniform Requirements for manuscripts submitted to biomedical journals and the ethical principles defined in the Farmington Consensus of 1997. Treści przedstawione w pracy są zgodne z zasadami Deklaracji Helsińskiej odnoszącymi się do badań z udziałem ludzi, ujednoliconymi wymaganiami dla czasopism biomedycznych oraz z zasadami etycznymi określonymi w Porozumieniu z Farmington w 1997 roku.

References/Piśmiennictwo

1. World Health Organization, International Agency for Research on Cancer. Alcohol drinking. IARC monographs on the evaluation of the carcinogenic risks to humans. Lyon: WHO Press; 1988, Vol. 44.
2. World Health Organization, International Agency for Research on Cancer. Alcohol consumption and ethyl carbamate. IARC monographs on the evaluation of carcinogenic risks to humans. Lyon: WHO Press; 2010, Vol. 96.
3. World Health Organization. World Cancer Report 2014. Geneva: WHO Press; 2015.
4. World Health Organization. Alcohol and cancer in the WHO European Region. An appeal for better prevention. Copenhagen: WHO Regional Office for Europe; 2020. https://apps.who.int/iris/bitstream/handle/10665/336595/WHO-EURO-2020-1435-41185-56004-eng.pdf?sequence=1&isAllowed=y (Accessed: June 2021).
5. Rehm J, Shield KD. Alcohol Use and Cancer in the European Union. Eur Addict Res 2021; 27: 1-8. DOI: https://doi:10.1159/000507017.
6. World Health Organization. 5 facts about alcohol and cancer. Copenhagen: WHO Regional Office for Europe; 2021. https://www.euro.who.int/__data/assets/pdf_file/0013/502312/alcohol-and-cancer-factsheet-eng.pdf (Accessed: June 2021).
7. Alcohol Awareness. New WHO study links moderate alcohol use with higher cancer risk; 2021. https://alcoholcampaign.org/2021/07/15/new-who-study-links-moderate-alcohol-use-with-higher-cancer-risk/ (Accessed: July 2021).
8. Pelucchi C, Tramacere I, Boffetta P, Negri E, La Vecchia C. Alcohol consumption and cancer risk. Nutr Cancer 2011; 63: 983-90. DOI: https://doi.org/10.1080/01635581.2011.596642.
9. Pöschl G, Seitz HK, Alcohol and cancer. Alcohol Alcohol 2004; 39: 155-65. DOI: https://doi.org/10.1093/alcalc/agh057.
10. Bagnardi V, Rota M, Botteri E, Tramacere I, Islami F, Fedirko V, et al. Light alcohol drinking and cancer: a meta-analysis. Ann Oncol 2013; 24: 301-8. DOI: https://doi.org/10.1093/annonc/mds337.
11. Shield KD, Soerjomataram I, Rehm J. Alcohol Use and Breast Cancer: A Critical Review. Alcohol Clini Exp Res 2016; 40: 1166-81. DOI: https://doi.org/10.1111/acer.13071.
12. Schütze M, Boeing H, Pischon T, Rehm J, Kehoe T, Gmel G, et al. Alcohol attributable burden of incidence of cancer in eight European countries based on results from prospective cohort study. BMJ 2011; 342: d1584. DOI: https://doi.org/10.1136/bmj.d1584.
13. Rumgay H, Shield K, Charvat H, Ferrari P, Sornpaisarn B, Obot I, et al. Global burden of cancer in 2020 attributable to alcohol consumption: a population-based study. Lancet Oncol 2021; 22: 1071-80. DOI: https://doi.org/10.1016/S1470-2045(21)00279-5.
14. Bocquier A, Fressard L, Verger P, Legleye S, Peretti-Watel P. Alcohol and cancer: risk perception and risk denial beliefs among the French general population. Eur J Public Health 2017; 27: 705-10.
15. Bowden JA, Delfabbro P, Room R, Miller C, Wilson W. Alcohol consumption and NHMRC guidelines: has the message got out, are people conforming and are they aware that alcohol causes cancer? Aust NZ J Public Health 2014; 38: 66-72.
16. Pettigrew S, Jongenelis M, Pratt IS, Liang W, Slevin T, Chikritzhs T, et al. Australian drinkers’ perceptions of alcohol-related risk by consumption status. Add Res Theory 2016; 24(6): 507-13. DOI: https://10.1080/16066359.2016.1175557.
17. Rehm J, Lachenmeier DW, Room R. Why does society accept a higher risk for alcohol than for other voluntary or involuntary risks? BMC Med 2014; 12: 189. DOI: https://doi:10.1186/s12916-014-0189-z.
18. Lizama N, Jongenelis M, Slevin T. Awareness of cancer risk factors and protective factors among Australian adults. Health Promot J Austral 2020; 31: 77-83. DOI: https://doi.org/10.1002/hpja.248.
19. Petticrew M, Hessari NM, Knai C, Weiderpass E. How alcohol industry organisations mislead the public about alcohol and cancer. Drug Alcohol Rev 2018; 37: 293-303.
20. Wojtyniak B, Stokwiszewski J, Goryński P, Trochnowicz A, Zdrojewski T, Rabczenko D. Długość życia i umieralność mieszkańców Polski. In: Wojtyniak B, Goryński P (eds.). Sytuacja zdrowotna mieszkańców Polski i jej uwarunkowania 2020. Warszawa: Narodowy Instytut Zdrowia Publicznego – Państwowy Zakład Higieny; 2020, p. 69-202.
21. Sierosławski J, Moskalewicz J, Mäkelä P, Gisle L, Palle C, Ghirini S, et al. Alcohol consumption. In: Moskalewicz J, Room R, Thom B (eds.). Comparative monitoring of alcohol epidemiology across the EU: Baseline assessment and suggestions for future action. Synthesis report RARHA. Warszawa: PARPA; 2016, p.73-101.
22. Zatoński WA, Janik-Koncewicz K, Zatoński M, Wojtyła A. Alkohol – ojciec polskich chorób. Menedżer Zdrowia 2021; 1: 82-7.
23. Zatoński WA, Zatoński M, Janik-Koncwicz K, McKee M. Alcohol-related liver cirrhosis in Poland: the reservoir effect. Lancet Gastroenterol Hepatol 2020; 5: 1035.
24. Buykx P, Li J, Gavens L, Hooper L, Lovatt M, Gomes de Matos E, et al. Public awareness of the link between alcohol and cancer in England in 2015: a population-based survey. BMC Public Health 2016; 16(1): 1194. DOI: https://doi.org/10.1186/s12889-016-3855-6.
25. Martin N, Buykx P, Shevills C, Sullivan C, Clark L, Newbury-Birch D. Population Level Effects of a Mass Media Alcohol and Breast Cancer Campaign: A Cross-Sectional Pre-Intervention and Post-Intervention Evaluation. Alcohol Alcohol 2018; 53(1): 31-8. DOI: https://doi:10.1093/alcalc/agx071.
26. Sjöberg L. Risk perception of alcohol consumption. Risk Anal 1998; 22: 277-84.
27. Flynn J, Slovic P, Mertz CK. Gender, race and environmental health risks. Risk Anal 1994; 14: 1101-8.
28. Gustafson PE. Gender differences in risk perception: theoretical and methodological perspectives. Risk Anal 1998; 18(6): 805-11.
29. Hopwood P. Breast cancer risk perception: what do we know and understand? Breast Cancer Res 2000; 2(6): 387-91. DOI: https://doi.org/10.1186/bcr83.
30. Asobayire A, Barley R. Women’s cultural perceptions and attitudes towards breast cancer: Northern Ghana. Health Promot Int 2015; 30(3): 647-57. DOI: https://doi.org/10.1093/heapro/dat087.
31. Rainey L, Jervaeus A, Donnelly LS, Evans DG, Hammarström M, Hall P, et al. Women’s perceptions of personalized risk-based breast cancer screening and prevention: An international focus group study. Psychooncology 2019; 28(5): 1056-62. DOI: https://doi.org/10.1002/pon.5051.
32. Dixon HG, Pratt IS, Scully ML, Miller JR, Patterson C, Hood R, et al. Using a mass media campaign to raise women’s awareness of the link between alcohol and cancer: cross-sectional pre-intervention and post-intervention evaluation surveys. BMJ Open 2015; 5. DOI: https://doi:10.1136/bmjopen-2014-006511.
33. Christensen A, Meyer M, Dalum P, Krarup AF. Can a mass media campaign raise awareness of alcohol as a risk factor for cancer and public support for alcohol related policies? Prev Med 2019; 126: 105722. DOI: https://doi.org/10.1016/j.ypmed.2019.05.010.
34. Scheideler JK, Klein WMP. Awareness of the link between alcohol consumption and cancer across the world: a review. Cancer Epidemiol Biomark Prev 2018; 27: 429-37. DOI: https://doi:10.1158/1055-9965.EPI-17-0645
This is an Open Access journal distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode), allowing third parties to download and share its works but not commercially purposes or to create derivative works.
facebook linkedin twitter
© 2022 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.