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Pediatric Endocrinology Diabetes and Metabolism
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Opis przypadku

Zespół włosowo-nosowo-paliczkowy jako diagnostyczne i terapeutyczne wyzwanie dla endokrynologa dziecięcego

Elżbieta Foryś-Dworniczak, Olimpia Zajdel-Cwynar, Barbara Kalina-Faska, Ewa Małecka-Tendera, Paweł Matusik

Pediatr Endocrinol Diabetes Metab 2019; 25 (1): 41-47
Data publikacji online: 2019/05/23
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Trichorhinopharyngeal syndrome (TRPS) is an autosomal dominant malformation syndrome, characterised by craniofacial and skel-etal abnormalities with variable expressivity [1]. The first case of TRPS was reported by Giedion in 1966 [2]. Three clinically and mo-lecularly distinguishable types of TRPS (TRPSs I, II, and III) have been described in the literature. TRPS type I (Giedion syndrome) is caused by alternations of chromosome 8 band q 24.1, including deletions, insertions, or translocations [1]. TRPS type II (Langer-Giedion syndrome, LGS) is a contiguous gene syndrome with larger deletion, involving loss of functional copies of the TRPS1 gene at 8q23.3 and EXT1 gene at 8q24.11 [3]. TRPS type III is almost exclusively caused by missense mutations in the GATA DNA-binding zinc finger of TRPS1 protein. Ludacke et al. (2001) suggested that TRPS III is a subclass of TRPS I, which is supposed to be at the severe end of the TRPS spectrum [4].
The TRPS1 gene was identified and mapped to chromosomal band 8q24 by Momeni et al. [1]. TRPS gene encode a zinc-finger, GATA-type transcription factor, which is involved in the development and differentiation of the bones, kidneys, and hair follicles [1]. In recent articles a possible role of TRPS1 in determining bone mineral density and influencing on bone homeostasis has been described [5, 6]. Mutations or haploinsufficiency at TRPS1 is the major cause of TRPS I and III. So far five molecular classes of TRPS1 mutation have been found: deletion or disruption, nonsense mutation, in-frame splice mutation, missense mutation, or no mutation identified [4]. The establishment of genotype-phenotype correlation revealed variability of clinical features.
EXT1 is a tumour suppressor gene, which encodes exostosin-1, and which, with EXT2, forms a hetero-oligomeric complex playing an essential role in the regulation of chondrocyte differentiation, ossification, and apoptosis. The loss of the both functional cop-ies of them causes multiple exostoses in TRPS type II. Mutations in EXT1 are also associated with development of chondrosarcoma [7, 8].
Trichorhinophalangeal syndrome is characterised by distinctive facial dysmorphic features and various skeletal abnormalities. The phenotype was variable and present a wide clinical spectrum. Features common to all three types are fine, slowly growing, sparse scalp hair, often of poor quality, breaking and pulling out easily. In addition, facial features also included pear-shaped nose with a bulbous tip, hypoplastic nasal alae nasi, low-set, protruding ears, and prominent malar eminence and orbital ridge. Highly characteristic are elongated philtrum, thin upper vermillion border, broad, laterally sparse eyebrows, and triangular face [2, 3, 9, 10]. Sparseness of hair may also affect the eyelashes, bear, axillary, and pubic hair [7]. Thin, fragile, slowly growing nails have been described. Additional nail changes in TRPS include leukonychia, koilonychia, onychodystrophy, and longitudinal striation [5, 11]. The oral changes, such as malocclusion, supernumerary teeth, microdontal teeth, hypodontia, and micrognathia or bilateral dysplasia of the mandibular condyles have been described in a few cases [12, 13].
The skeletal abnormalities include short stature, brachio- and clinodactyly, short metacarpal phalanges, short feet and metatar-sals, winged scapula, pectus carinatum, and scoliosis [2]. In addition, in TRPS II patients joint hyper-extensibility, syndactyly, and pre-disposition to fracture can occur.
The most typical radiographic findings are cone-shaped epiphyses (CSEs), mostly at the middle phalanges. They can be unde-tectable before two years of age [4]. However, in some cases, the first manifestation of CSEs could be mild metaphyseal convexity [14]. CSEs irregular growth of phalanges and premature closure of growth plates leads to clino- and brachydactyly. Furthermore, those changes can also be found at other tubular bones. Hip malformation such as coxa magna, coxa plana, or coxa vara are present in more than 70% of patients [4]. The skeletal age is retarded behind the chronological age until puberty and then typically accelerates. Grow retardation occurs in the postnatal period and is a progressive process [2, 4, 5]. Evaluation of skeletal abnormalities reveal a wide clinical spectrum, but it is found that patients with missense mutation tend to be more severely affected than patients with nonsense mutations.
Trichorhinopharyngeal syndrome type II differs from TRPS type I by the presence of multiple exostoses and mild to severe mental retardation [4]. TRPS type II/LGS is also associated with laxity of joints, looseness of the skin, microcephaly, deep-set eyes, exotropia, tented, thickened nasal alae, and conductive hearing loss [15]. TRPS type III differs clinically from TRPS I by the presence of severe brachydactyly, due to short metacarpals and severe short stature [3].
In addition, malformations of inner organs have been reported in the literature, as well. Besides disorders of the ureter-bladder junction, vesicoureteral reflux, renal defect [9] heart failure like ventricular septal defects (VSD), or mitral valve prolapse (MVP) have been described in several patients [16-18]. Growth hormone deficiency, hypothyroidism, or diabetes mellitus was previously reported in a few cases [19].

Case reports

This report presents a series of four cases of TRPS (three sporadic and one familial). Clinical presentation included typical facial dysmorphic features (pear-shaped nose, long, flat philtrum, thin upper vermilion border, and protruding ears), thin, sparse scalp hair, and different skeletal abnormalities with normal mentation.

Case 1

A 5.5-year-old boy with short stature was referred to the department of endocrinology for growth retardation. The diagnosis of TRPS was suggested based on typical craniofacial features including triangular face, bulbous, pear-shaped nose, elongated philtrum, sparse and slow-growing hair, rarefaction of the lateral eyebrow portion, and protruding ears.
He was born as the third child of non-consanguineous parents. Pregnancy was complicated by incompetence of the cervix uteri, and Caesarean section was performed at gestational week 37. Birth weight was 2900 g, and length was 53 cm. Psychomotor de-velopment was appropriate, but after the first year of life the patient manifested growth failure. At the age of two years, he was hospital-ised on the department of gastroenterology due to growth deficiency. Thorough examination of the patient and laboratory analyses did not confirm malabsorption syndrome. During presentation, his height was 103.6 cm (< 3rd centile), weight was 16.3 kg (3rd centile), and BMI was 15.2 (25-50th centile). Physical examination showed typical facial dysmorphic features and short stature. Clinically there were no skeletal abnormalities, but radiological assessment confirmed cone-shaped epiphyses at the phalanges and delayed skeletal maturation (Fig. 1). General laboratory tests of blood and urine were normal, and GH provocation test with clonidine showed proper GH peaks. No disturbances of calcium-phosphate metabolism were found (Table 1). Moreover, the patient’s father and one of his brothers mani-fested a similar phenotype (not genetically confirmed yet).

Case 2

A 12-year-old girl hospitalised with growth velocity retardation, with clinical and radiological epiphyseal deformities in phalanges, right humerus, and brachydactyly of toes.
She was born as the first child of healthy, non-consanguineous parents. Both parents and a younger sister were healthy and of normal height. She was born at gestational week 40, birth weight was 2900 g, and length was 52 cm. The postnatal period was compli-cated by uretero-pelvic junction stricture. Additionally, she had belatedly overgrowing of fontanelle. During the first years of life the girl manifested failure to thrive, delayed psychomotor development, and hyper-flexible joints. Her parents mentioned that she had no hair growth until the age of three years and now had thin scalp hair of poor quality, easily broken and pulling out. From the age of 10 years, she had been suffering from chronic pain of hand joints.
At the time of hospitalisation, the patient’s height was 148.5 cm (10th-25th centile), and weight was 40.6 kg (25th-50th centile). Physical examination showed typical TRPS I craniofacial and skeletal abnormalities such as sparse, slowly growing hair, a bulbous, pear-shaped nose, and short stature. Moreover, she had triangular face, laterally sparse eyebrows, thin upper vermillion border, long, flat philtrum, and protruding ears, which is highly characteristic. Radiographic examination revealed bone age retardation (bone age 11 years vs. 12 years and 3 months of chronological age). Her hands were remarkable for clino- and brachydactylia. She had short, flat feet and knock-knees. The most severe skeletal abnormality was shoulder joint deformity with limitation of radiation and abduction. Endocrino-logical evaluation revealed normal level of thyroid hormones, cortisol, parathyroid hormone, and IGF-1. Apart from mild 25-OH D3 insufficiency, no disturbances of calcium and phosphate balance were observed (Table 1). MRI of the brain and pituitary region were normal. Genetic analysis revealed interstitial heterozygous microdeletion of 8q24 and confirmed TRPS type 1 diagnosis.

Case 3

A 13.5-year-old girl with short stature (GH deficiency excluded), typical epiphyseal deformities in phalanges, and Perthes-like left hip deformation.
The girl was admitted to the department of endocrinology for diagnosis of short stature. She was born at the 37th week of ges-tation with low birth weight (2000 g, < 3rd centile) and short length (44 cm, < 3rd centile). The patient’s mother smoked and abused al-cohol during pregnancy. Significant failure to thrive was noted, with length and weight remaining below the 3rd centile. The psychomo-tor development was assessed as below average for the child’s age. A neurodevelopmental disorder was recognised. She had positive medical history of Perthes disease-like left femoral head changes and left coxa subluxation. In addition, she had recurrent urinary tract infections. Genetic analysis confirmed interstitial heterozygous microdeletion of 8q24.
During presentation her height was 144.9 cm (< 3rd centile) and her weight was 35.8 kg (< 3rd centile). The physical examina-tion revelled facial dysmorphic features including pear-shaped nose and long philtrum, wide mouth with thin upper lip, micrognathia, protruding ears, and sparse hair (Fig. 2). Ulnar deviation of II digits and radial deviation of IV digits of both hands at the proximal in-terphalangeal joint were also observed (Fig. 3). Examination of the patient’s feet showed minor syndactyly of II and III toes, shortening of I, IV, and V metacarpals, and hypoplastic nails (Fig. 4). Radiographic examination showed skeletal abnormalities, such as cone-shaped epiphyses of the middle and proximal phalanges and shortened metacarpal IV. The bone age was the same as her biological age. GH provocation test with clonidine showed proper GH peaks. The levels of thyroid hormone, cortisol, parathyroid hormone, LH, FSH, and E2 were normal. However, endocrinological evaluation revealed mildly decreased 25-hydrokxyvitamin D level and elevated alkaline phosphatase level. The result of 24-hour urine collection showed border calcium excretion, and the phosphate resorption rate was within the normal range (Table 1). MRI of the brain and pituitary region was appropriate. Interestingly, no TRPS features were found in her twin sister.

Case 4

An 11-year-old girl was referred to the Department of Paediatrics and Paediatric Endocrinology due to short stature with concomi-tant facial dysmorphic features with the suspicion of Turner Syndrome.
She was born as the first child of no consanguineous parents, by natural delivery, at gestational week 39. Her birth weight was 2960 g and length was 49 cm. The psychophysical development during the postnatal period was normal. Significant failure to thrive was noted at the age of five years. Bilateral Perthes disease was recognised at the age of six years.
On admission to the hospital at age 11 years, the patient’s length was 124.3 cm (9 cm below the 3rd centile) and her weight was 36.9 kg (25th-50th centile). Physical examination showed facial dysmorphic features (triangular face, micrognathia, high-arched palate, flat philtrum) and sparse, thin hair. Laboratory findings revealed reduced level of growth hormone in nocturnal GH spontaneous secre-tion and in the two stimulation tests (with clonidine and insulin); the level of night cortisol was elevated. The test with dexamethasone excluded adrenal failure. The function of thyroid gland and the level of prolactin, LH, and FSH were normal (Table 1). The results of complete blood count, renal and liver function, blood glucose, and routine urinalysis were within normal ranges. However, endocrinolo-gy evaluation revealed mildly decreased 25-hydrokxyvitamin D level; no additional disturbances of calcium and phosphate balance were observed.
The bone age, performed according to the Greulich and Pyle method, was significantly delayed (bone age 6 years and 10 months vs. 11 years of chronological age). The radiograph of hands also exposed middle phalange cone-shaped epiphyses, middle pha-langes of IV and V fingers, ulnarisation, and shortened metacarpal IV. Chromosomal studies on peripheral lymphocyte culture showed a 46,XX normal female karyotype. MRI of the brain and hypothalamic-hypophyseal region showed a cyst or microadenoma complicat-ed by haemorrhage. She was qualified to GH therapy. GH substitution with 0.9 mg/day was started and provided to an increase of height velocity from 4.3 cm to 8.5 cm/year during the first year of treatment. No adverse events were observed. The therapy lasted for three years; nevertheless, the patient’s final height remained below the 3rd centile (–3,1 HSDS).


Trichorhinopharyngeal syndrome is a rare, autosomal dominant skeletal dysplasia caused by a defect involving the TRPS1 gene on chromosome 8. The syndrome is characterised by the common triad of hair, craniofacial, and skeletal abnormalities [1, 9, 11, 14]. Mani-festations of the disease present a wide clinical spectrum. The phenotype is variable even in patients with identical mutations or in MZ twins [4, 19, 20]. To date, a few hundred cases of TRPS have been described in the literature, but probably many cases remain undiag-nosed or misdiagnosed.
In one of the index patients the disease was probably of autosomal dominant inheritance, because the same disorder was appar-ent amongst his parents and siblings. The other three individuals were apparently sporadic cases. Three of our patients were female and one was male. All of them presented the typical facial appearance with pear-shaped nose with a bulbous tip, long philtrum, wide mouth, thin upper vermilion border, and fine, sparse hair. It is relevant that the one of the presenting patients had almost complete absence of scalp hair at the age of three years.
Short stature is a common finding in affected individuals [21]. Three of our patients had height below the third centile. The evaluation of growth hormone axis revealed adequate endogenous growth hormone secretion in two of the presented cases. One of the affected children was found to have partial GH deficiency and was qualified to GH replacement therapy. A remarkable catch-up growth after the beginning of the treatment was observed.
Recent studies have indicated the possible role of TRPS1 in bone homeostasis, especially in determining bone mineral density. Endocrinology evaluation revealed mildly decreased 25-hydrokxyvitamin D level in three of the index patients. However, no serious additional disturbances of calcium and phosphate balance were observed.
Trichorhinopharyngeal syndrome is also connected with typical skeletal abnormalities [2, 4, 9, 10]. The clinical examination in the majority of presenting patients revealed irregularly short and stubby hands, with clinodactyly of at least one finger. Radiographs, in all of the cases, showed an enlarged, irregular metaphyseal ending, with the shape of a cone or an inverted V. One or more metacarpals were short in two of the index patients. Additionally, in most of the individuals, the skeletal age compared with the chronological age was retarded. However, the cone-shaped epiphyses of phalanges are found in many other skeletal dysplasias and also occur in about 5% of normal children.
Trichorhinopharyngeal syndrome can also mimic juvenile idiopathic arthritis or Perthes disease [11, 22, 23]. One of the index patients presented several atypical rheumatological symptoms, including interphalangeal asymmetric arthritis, and had hypermobility of the joints. She also suffered from chronic hand joint pain and had limitated arm movement.
One of the individuals had Perthes-like left hip deformation, and another had surgical intervention due to bilateral Perthes dis-ease. In cases with bilateral changes affecting the hips, multiple epiphyseal dysplasia must be considered.
The differential diagnosis in patients with alopecia and abnormalities of the nose and hands, also includes the oral-facial-digital syndrome, Larsen’s syndrome, alopecia-onychodysplasia, hidrotic ectodermal dysplasia (Cloustron’s syndrome), chondroectodermal dysplasia (Ellis-van Creveld syndrome), and Coffin-Siris syndrome [18].
A few studies showed a connection between TRPS and malformation of other organs, including genitourinary tract disorder, mitral valve prolapse, or ventricular septal defect. One of the presented patients had a connate uretero-pelvic junction stricture that re-quired pyeloplasty.
It can be concluded that despite the rarity of the TRPS, primary care physicians, paediatricians, rheumatologists, and endocri-nologists should consider this diagnosis when evaluating individuals with characteristic trichological, facial, and skeletal abnormalities. It is noteworthy that clinical features of TRPS may mimic other skeletal dysplasias, Perthes disease or inflammatory arthropathy. The physical examination, radiological findings and genetic analysis are meaningful for diagnosing patients with TRPS. It is postulated that the level of 25-hydroxyvitamin D and DXA scan for affected children and adolescent may be helpful in the detection of early phase osteopaenia and to prevent the development of severe osteoporosis in adulthood. Functional disability or chronic arthralgias may be corrected by orthopaedic procedures.
Several studies showed a possible association between TRPS and growth hormone deficiency and other endocrine disturb-ances. The affected individuals with short stature need evaluation of the growth hormone axis. It is suggested that GH therapy could improve growth and bone mineral density in children with growth failure [24, 25].
TRPS may be associated also with renal alteration, genitourinary track malformation, and heart pathology. This fact indicates that TRPS is a multisystemic disorder. At present, specific treatments for TRPS are not available. The cooperation of a multidisciplinary team seems to be essential in the proper management of these patients. Indeed, proper clinical and genetic diagnosis allows adequate and timely therapeutic intervention.


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