Analysis of risk factors affecting the development 
of peptic ulcer perforation: case-control study

Sami Akbulut; Ali Caliskan; Hasan Saritas; Khaled Demyati; Yilmaz Bilgic; Selver Unsal; Cemalettin Koc; Sezai Yilmaz

doi:10.5114/pg.2020.94744

eISSN: 1897-4317
ISSN: 1895-5770

Gastroenterology Review/Przegląd Gastroenterologiczny

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1/2021
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abstract:

Original paper

Analysis of risk factors affecting the development of peptic ulcer perforation: case-control study

Sami Akbulut

¹

,

Ali Riza Caliskan

²

,

Hasan Saritas

³

,

Khaled Demyati

^{1, 4}

,

Yilmaz Bilgic

²

,

Selver Unsal

⁵

,

Cemalettin Koc

¹

,

Sezai Yilmaz

¹

Department of Surgery and Liver Transplant Institute, Faculty of Medicine, Inonu University, Malatya, Turkey
Department of Gastroenterology, Faculty of Medicine, Inonu University, Malatya, Turkey
Department of Surgical Nursing, Faculty of Health Sciences, Inonu University, Malatya, Turkey
Department of Surgery, An-Najah National University Hospital, An-Najah National University, Nablus, Palestine
Department of Nursing Service, Inonu University, Malatya, Turkey

Gastroenterology Rev 2021; 16 (1): 23–28

DOI: https://doi.org/10.5114/pg.2020.94744

Online publish date: 2020/04/25

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Aim
The aim of the to determine the risk factors associated with increased risk of peptic ulcer perforation (PUP)

Material and methods
The demographic, clinic, and biochemical parameters of 65 patients (PUP group) who underwent PUP surgery at our clinic between June 2009 and September 2016 were compared with the data of 134 patients (control group) who underwent endoscopy at a gastroenterology clinic for dyspeptic complaints. The control group were matched at random in a 1 : 2 ratio with the PUP group. Univariate analyses were used to compare different variables and variables with clinical significance, and p ≤ 0.05 was used in the backward stepwise logistic regression model.

Results
This study included 65 patients with peptic ulcer perforation aged 17 to 92 years (PUP group) and 134 patients with dyspeptic complaints aged 18 to 87 years (control group). Univariate analysis showed that statistically significant differences were found between groups in terms of non-steroidal anti-inflammatory drugs usage (p = 0.042; OR = 1.868), smoking (p < 0.001; OR = 5.124), old age (p = 0.003), low body mass index (BMI) (p < 0.001), and low hemoglobin (Hb) (p = 0.002). However multivariate analysis showed that increasing age (p = 0.004; OR = 1.035), smoking (p = 0.007; OR = 3.591), decreasing Hb (p = 0.042; OR = 1.277), and decreasing BMI (p < 0.001; OR = 1.669) were independent clinically significant risk factors for development of PUP.

Conclusions
This study showed that decreased BMI, decreased Hb, increased age, and smoking were independent risk factors for development of PUP. Thus, this group of patients needs particular attention paid to suggestive symptoms with early diagnosis and optimal management of peptic ulcer disease.

keywords:

Analysis of risk factors affecting the development of peptic ulcer perforation: case-control study

Sami Akbulut 1 , Ali Riza Caliskan 2 , Hasan Saritas 3 , Khaled Demyati 1, 4 , Yilmaz Bilgic 2 , Selver Unsal 5 , Cemalettin Koc 1 , Sezai Yilmaz 1

peptic ulcer, perforation, risk factors

Sami Akbulut

¹

,

Ali Riza Caliskan

²

,

Hasan Saritas

³

,

Khaled Demyati

^{1, 4}

,

Yilmaz Bilgic

²

,

Selver Unsal

⁵

,

Cemalettin Koc

¹

,

Sezai Yilmaz

¹