Health Problems of Civilization
eISSN: 2354-0265
ISSN: 2353-6942
Health Problems of Civilization Physical activity: diseases and issues recognized by the WHO
Bieżący numer Archiwum Online first O czasopiśmie Rada naukowa Recenzenci Bazy indeksacyjne Kontakt Zasady publikacji prac Opłaty publikacyjne Standardy etyczne i procedury
Panel Redakcyjny
Zgłaszanie i recenzowanie prac online
SCImago Journal & Country Rank
Poleć ten artykuł:
Udostępnij:
streszczenie artykułu:
Artykuł oryginalny

CORRELATION BETWEEN HBSAG QUANTITATIVE ASSAY RESULTS AND HBV-DNA LEVELS IN CHRONIC HEPATITIS B PATIENTS: A SINGLE-CENTER EXPERIENCE

Zhivka Stoykova
1
,
Tsvetelina Kostadinova
2, 3
,
Teodora Katrandzhieva
1, 2
,
Irina Ivanova
2, 4
,
Tatina Todorova
1, 2

  1. Department of Microbiology and Virology, Medical University of Varna, Bulgaria
  2. University Hospital ”St. Marina”, Varna, Bulgaria
  3. Medical College, Medical University of Varna, Bulgaria
  4. Department of Internal Medicine, Medical University of Varna, Bulgaria
Health Problems of Civilization
Data publikacji online: 2025/06/10
Pełna treść artykułu Pobierz cytowanie
 
Metryki PlumX:


Background
Quantifying hepatitis B virus (HBV) DNA is the main laboratory test for diagnosis and monitoring of patients with chronic HBV infection (CHB). Such assays are molecular-based and often expensive for health systems worldwide. Measure of HBV surface antigen (HBsAg) levels by automated chemiluminescent immunoassay (CLIA) has been proposed as a surrogate and cost-effective marker that may simplify HBV management. In this study, we determined whether quantitative HBsAg levels correlate with HBV-DNA levels in a cohort of CHB patients.

Material and methods
This cross-sectional study was performed in the Laboratory of Virology, ‘‘St. Marina’’ University Hospital, Varna, Bulgaria, from January 2022 to December 2024. In total, 315 serum samples from CHB patients were obtained, and HBsAg, HBV-DNA and HBV early antigen (HBeAg)/anti-HBe levels were measured.

Results
The Spearman’s rank correlation between the HBsAg and HBV-DNA in the entire sample was 0.51 with a p-value <0.001. In the HBeAg-negative patients, the correlation coefficient was 0.49, and in HBeAg-positive – 0.49 (both p-values <0.001).

Conclusions
HBsAg levels, measured by chemiluminescence assay, moderately correlated with HBV-DNA levels in CHB patients from Varna, Bulgaria. The correlation’s strength was not related to the individuals’ HBeAg status.


© 2025 Termedia Sp. z o.o.
Developed by Bentus.