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ISSN: 1895-5770
Gastroenterology Review/Przegląd Gastroenterologiczny
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vol. 13
Original paper

Can serum progranulin levels be a biomarker following gastric ulcer therapy?

Evrim Kahramanoğlu Aksoy, Ferdane Sapmaz, Özlem Doğan, Özgür Albuz, Metin Uzman, Yaşar Nazlıgül

Gastroenterology Rev 2018; 13 (4): 313–321
Online publish date: 2018/12/11
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Progranulin is a novel growth factor that has several physiological and pathological roles such as cell growth, tumourigenesis, embryogenesis, wound healing, and inflammation.

To compare the pre-treatment and post-treatment serum levels of the angiogenic factor vascular endothelial growth factor (VEGF), pro-inflammatory cytokine tumor necrosis factor  (TNF-), and progranulin in peptic ulcer (PU) patients with a healthy control group.

Material and methods
Serum VEGF, TNF-, and progranulin levels were studied with ELISA in 42 PU patients (antral ulcer (AU): 22, duodenal ulcer (DU): 20) and 15 healthy controls.

The serum progranulin levels before treatment were 4237.35 ±1091.30 pg/ml in the patients with AU, 4682.64 ±1501.46 pg/ml in the patients with DU, 3055.66 ±626.88 pg/ml in the control group, and 4460 ±1315 pg/ml in the ulcer (AU and DU) group. The serum progranulin levels were 3607.7 ±869.4 pg/ml in the AU group, 4286.5 ±1208.78 pg/ml in the DU group, and 3947.1 ±1094.64 pg/ml in the ulcer group after the treatment. When comparing pre-treatment serum progranulin levels of the AU group, DU group, and ulcer group with the control group there were statistically significant differences (p < 0.001, p < 0.0001, p < 0.0001, respectively).

The disappearance of the difference in terms of post-treatment serum levels of progranulin between the AU group and the control group suggests that serum levels of progranulin can be used as a biomarker of gastric ulcer healing.


peptic ulcer, progranulin, tumor necrosis factor , vascular endothelial growth factor

Lanas A, Chan FKL. Peptic ulcer disease. Lancet 2017; 390: 613-24.
Yeomans ND. The ulcer sleuths: the search for the cause of peptic ulcers. J Gastroenterol Hepatol 2011; 26 Suppl 1: 35-41.
Brzozowska I, Targosz A, Sliwowski Z, et al. Healing of chronic gastric ulcers in diabetic rats treated with native aspirin, nitric oxide (NO) derivative of aspirin and cyclooxygenase (COX)-2 inhibitor. J Physiol Pharmacol 2004; 55: 773-90.
Hudson N, Balsitis M, Everitt S, Hawkey CJ. Angiogenesis in gastric ulcers: impaired in patients taking non-steroidal anti-inflammatory drugs. Gut 1995; 37: 191-4.
Tarnawski AS, Ahluwalia A. Molecular mechanisms of epithelial regeneration and neovascularization during healing of gastric and esophageal ulcers. Curr Med Chem 2012; 19: 16-27.
Wozniak-Holecka J, Josko J, Tyrpien M, et al. Influence of vascular endothelial growth factor (VEGF) on gastroprotection in stress-induced gastric mucosal ulcers in rats. Methods Find Exp Clin Pharmacol 2009; 31: 523-31.
Tarnawski AS, Ahluwalia A, Jones MK. Angiogenesis in gastric mucosa: an important component of gastric erosion and ulcer healing and its impairment in aging. J Gastroenterol Hepatol 2014; 29 Suppl 4: 112-23.
Jones MK, Itani RM, Wang H, et al. Activation of VEGF and Ras genes in gastric mucosa during angiogenic response to ethanolinjury. Am J Physiol 1999; 276: G1345-55.
Lahiri S, Sen T, Palit G. Involvement of glucocorticoid receptor and peroxisome proliferator activated receptor-gamma in pioglitazone mediated chronic gastric ulcer healing in rats. Eur J Pharmacol 2009; 609: 118-25.
Luo JC, Cho CH, Ng KM, et al. Dexamethasone inhibits tumor necrosis factor-alpha-stimulated gastric epithelial cell migration. J Chin Med Assoc 2009; 72: 509-14.
He Z, Bateman A. Progranulin (granulin-epithelin precursor, PC-cell derived growth factor, acrogranin) mediates tissue repair and tumorigenesis. J Mol Med (Berl) 2003; 81: 600-12.
Ong CH, Bateman A. Progranulin (granulin-epithelin precursor, PC-cell derived growth factor, acrogranin) in proliferation and tumorigenesis. Histol Histopathol 2003; 18: 1275-88.
Jian J, Konopka J, Liu C. Insights into the role of progranulin in immunity, infection, and inflammation. J Leukoc Biol 2013; 93: 199-208.
Cenik B, Sephton CF, Kutluk Cenik B, et al. Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration. J Biol Chem 2012; 287: 32298-306.
He Z, Ong CH, Halper J, Bateman A. Progranulin is a mediator of the wound response. Nat Med 2003; 9: 225-9.
Tang W, Lu Y, Tian QY, et al. The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice. Science 2011; 332: 478-84.
He Z, Ismail A, Kriazhev L, et al. Progranulin (PC-cell-derived growth factor/acrogranin) regulates invasion and cell survival. Cancer Res 2002; 62: 5590-6.
Line A, Stengrevics A, Slucka Z, et al. Serological identification and expression analysis of gastric cancer-associated genes. Br J Cancer 2002; 86: 1824-30.
Wang H, Sun Y, Liu S, et al. Upregulation of progranulin by Helicobacter pylori in human gastric epithelial cells via p38MAPK and MEK1/2 signaling pathway: role in epithelial cell proliferation and migration. FEMS Immunol Med Microbiol 2011; 63: 82-92.
Tarnawski AS. Cellular and molecular mechanisms of gastrointestinal ulcer healing. Dig Dis Sci 2005; 50 Suppl 1: S24-33.
Barrientos S, Brem H, Stojadinovic O, et al. Clinical application of growth factors and cytokines in wound healing. Wound Repair Regen 2014; 22: 569-78.
Deng X, Xiong X, Khomenko T, et al. Inappropriate angiogenic response as a novel mechanism of duodenal ulceration and impaired healing. Dig Dis Sci 2011; 56: 2792-801.
Brzozowska I, Targosz A, Sliwowski Z, et al. Healing of chronic gastric ulcers in diabetic rats treated with native aspirin, nitric oxide (NO)-derivative of aspirin and cyclooxygenase (COX)-2 inhibitor. J Physiol Pharmacol 2004; 55: 773-90.
Pohle T, Shahin M, Domschke W, et al. Effect of basic fibroblast growth factor on gastric ulcer healing and its own mRNA expression. Aliment Pharmacol Ther 1999; 13: 1543-51.
Tkaczuk KR, Yue B, Zhan M, et al. Increased circulating level of the survival factor GP88 (progranulin) in the serum of breast cancer patients when compared to healthy subjects. Breast Cancer (Auckl) 2011; 5: 155-62.
Abella V, Pino J, Scotece M, et al. Progranulin as a biomarker and potential therapeutic agent. Drug Discov Today 2017; 22: 1557-64.
Goll R, Cui G, Olsen T, et al. Alterations in antral cytokine gene expression in peptic ulcer patients during ulcer healing and after Helicobacter pylori eradication. Scand J Immunol 2008; 67: 57-62.
Maev IV, Gorban VV, Salova LM. Blood flow and morphofunctional status of gastroduodenal mucosa in different phases of peptic ulcer. Ter Arkh 2007; 79: 57-61.
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